皖南医学院学报
皖南醫學院學報
환남의학원학보
ACTA ACADEMIAE MEDICINAE WANNAN
2013年
5期
374-375,376
,共3页
尿胰蛋白酶原-2%急性胰腺炎%淀粉酶%脂肪酶
尿胰蛋白酶原-2%急性胰腺炎%澱粉酶%脂肪酶
뇨이단백매원-2%급성이선염%정분매%지방매
urine trypsinogen-2%acute pancreatitis%amylase%lipase
目的：评价尿胰蛋白酶原-2快速检测在急性胰腺炎早期诊断中的价值。方法：检测85例因急性腹痛而就诊的急诊或住院的病人血、尿淀粉酶，血脂肪酶及尿胰蛋白酶原-2，按照《胰腺炎诊断标准》判断是否患有胰腺炎，分为急性胰腺炎组和非急性胰腺炎组，计算尿胰蛋白酶原-2阳性诊断急性胰腺炎的性能指标，以临床诊断急性胰腺炎统计尿胰蛋白酶原-2、血淀粉酶、尿淀粉酶的ROC曲线及尿胰蛋白酶原-2阳性在尿液中持续时间。结果：尿胰蛋白酶原-2诊断急性胰腺炎的特异度89．2％，敏感度97．9％，阴性预示值97．1％，阳性预测值92．2％，准确性94．1％。与血清淀粉酶比较P＞0．05，与尿淀粉酶比较P＜0．05，尿TPS-2、血淀粉酶、尿淀粉酶的ROC 曲线下的面积分别为0．860、0．823、0．821。结论：尿胰蛋白酶原-2快速检测简便、快速、微量、特异，为AP 的早期实验室诊断提供更加特异、准确的诊断依据。
目的：評價尿胰蛋白酶原-2快速檢測在急性胰腺炎早期診斷中的價值。方法：檢測85例因急性腹痛而就診的急診或住院的病人血、尿澱粉酶，血脂肪酶及尿胰蛋白酶原-2，按照《胰腺炎診斷標準》判斷是否患有胰腺炎，分為急性胰腺炎組和非急性胰腺炎組，計算尿胰蛋白酶原-2暘性診斷急性胰腺炎的性能指標，以臨床診斷急性胰腺炎統計尿胰蛋白酶原-2、血澱粉酶、尿澱粉酶的ROC麯線及尿胰蛋白酶原-2暘性在尿液中持續時間。結果：尿胰蛋白酶原-2診斷急性胰腺炎的特異度89．2％，敏感度97．9％，陰性預示值97．1％，暘性預測值92．2％，準確性94．1％。與血清澱粉酶比較P＞0．05，與尿澱粉酶比較P＜0．05，尿TPS-2、血澱粉酶、尿澱粉酶的ROC 麯線下的麵積分彆為0．860、0．823、0．821。結論：尿胰蛋白酶原-2快速檢測簡便、快速、微量、特異，為AP 的早期實驗室診斷提供更加特異、準確的診斷依據。
목적：평개뇨이단백매원-2쾌속검측재급성이선염조기진단중적개치。방법：검측85례인급성복통이취진적급진혹주원적병인혈、뇨정분매，혈지방매급뇨이단백매원-2，안조《이선염진단표준》판단시부환유이선염，분위급성이선염조화비급성이선염조，계산뇨이단백매원-2양성진단급성이선염적성능지표，이림상진단급성이선염통계뇨이단백매원-2、혈정분매、뇨정분매적ROC곡선급뇨이단백매원-2양성재뇨액중지속시간。결과：뇨이단백매원-2진단급성이선염적특이도89．2％，민감도97．9％，음성예시치97．1％，양성예측치92．2％，준학성94．1％。여혈청정분매비교P＞0．05，여뇨정분매비교P＜0．05，뇨TPS-2、혈정분매、뇨정분매적ROC 곡선하적면적분별위0．860、0．823、0．821。결론：뇨이단백매원-2쾌속검측간편、쾌속、미량、특이，위AP 적조기실험실진단제공경가특이、준학적진단의거。
Objective:To assess the value of rapid measurement of urina-ry trypsinogen-2(TPS-2)for early diagnosis of acute pancreatitis(AP). Methods:Blood and urine amylase,lipase and TPS-2 were determined in 88 emergency cases or inpatients with acute abdominal pain for initial di-agnosis on the Guidelines for Diagnosis and Treatment of Acute Pancreati-tis in China basis.The total patients were then allocated to group of AP and non-AP,and the diagnostic accuracy of the markers of TPS-2 were e-valuated by receiver-operating characteristic( ROC) curve analysis pertain-ing to the urine TPS-2,serum amylase and urine amylase as well as re-solved time of TPS-2 in the urine.Results:The specificity and sensitivity for AP by determination of TPS-2 were 89.2% and 97.1%,and the nega-tive predictive value,positive predictive value and accuracy of urine TPS-2 were 97.1%,92.2% and 94.1%,respectively.The difference was not significant with the reference values of serum amylase(P>0.05),yet was significant compared with urine amylase(P<0.05).The area under the curve of the ROC plot described urine TPS-2,serum amylase and urine amylase by 0.860,0.823 and 0.821, respectively.Conclusion:Urine TPS-2 dipstick test may be simple and quick for early diagnosis of AP for its higher specificity,sensitivity and accuracy.
