CAJ | 학술논문

目的分析胃间质瘤外科治疗效果及生存分析。方法59例胃间质瘤患者均行根治性手术，分析外科治疗疗效、预后因素及5年生存率。结果59例患者失访2例，17病例死亡，其余术后恢复均良好。患者总体1、3和5年生存率分别98.31%、83.12%和71.22%。肿瘤大小、核分裂象、胃外器官受累或伴发胃癌、恶性潜能分级与患者预后相关，差异均有统计学意义（χ2分别=6.78、10.12、5.71、7.79，P均＜0.05）。甲磺酸伊马替尼治疗与患者预后无明显相关性，差异无统计学意义（χ2=1.21，P＞0.05）。多因素生存分析显示，肿瘤大小和核分裂象是胃间质瘤的独立预后因素（OR分别=3.13、3.94，P均＜0.05）。结论胃间质瘤外科治疗疗效较好，5年生存率较高，且肿瘤大小及核分裂像是胃间质瘤的预后因素。
목적분석위간질류외과치료효과급생존분석。방법59례위간질류환자균행근치성수술，분석외과치료료효、예후인소급5년생존솔。결과59례환자실방2례，17병례사망，기여술후회복균량호。환자총체1、3화5년생존솔분별98.31%、83.12%화71.22%。종류대소、핵분렬상、위외기관수루혹반발위암、악성잠능분급여환자예후상관，차이균유통계학의의（χ2분별=6.78、10.12、5.71、7.79，P균＜0.05）。갑광산이마체니치료여환자예후무명현상관성，차이무통계학의의（χ2=1.21，P＞0.05）。다인소생존분석현시，종류대소화핵분렬상시위간질류적독립예후인소（OR분별=3.13、3.94，P균＜0.05）。결론위간질류외과치료료효교호，5년생존솔교고，차종류대소급핵분렬상시위간질류적예후인소。
Objective To analyze the clinical effect and survival analysis of 59 patients with gastric stromal tumors (GIST). Methods A total of 59 patients with gastric GIST underwent the radical operation. The clinical effect, prognostic factors and 5-year survival rate were analyzed. Results Two patients lost to follow-up and seventeen patients were dead in 59 patients. The others were recovered well. The overall survival rates of 1-yaer,3-year,5-year were 98.31%,83.12%and 71.22% respectively. Tumor size,mitotic activity,and Fletcher’ classification were associated with survival rates (χ2=6.78, 10.12, 7.79, P<0.05), but the therapy of imatinib mesylate was not associated with survival rates (χ2=1.21,P<0.05).Cox regression multivariable analysis showed that tumor size and mitotic activity were independent prognostic factors of GIST (OR=3.13, 3.94, P<0.05). Conclusion The clinical effect of GIST is good and 5-year survival rate is high to some extent. The tumor size and mitotic activity were independent prognostic factors of GIST.