全科医学临床与教育
全科醫學臨床與教育
전과의학림상여교육
CLINICAL EDUCATION OF GENERAL PRACTICE
2013年
5期
514-517
,共4页
原发性高血压%辛伐他汀%阿司匹林低生化反应%血小板聚集率%内皮功能
原髮性高血壓%辛伐他汀%阿司匹林低生化反應%血小闆聚集率%內皮功能
원발성고혈압%신벌타정%아사필림저생화반응%혈소판취집솔%내피공능
essential hypertension%simvastatin%aspirin low biochemical responsiveness%platelet aggregation rate%endothelial function
目的探讨辛伐他汀对高血压病合并高脂血症及阿司匹林低生化反应患者内皮功能及血小板聚集率的影响。方法采用前瞻性随机对照研究，口服肠溶阿司匹林片1周后，高血压病合并高脂血症及阿司匹林低生化反应患者109例入选，检测用花生四烯酸（AA）和二磷酸腺苷（ADP）作诱导剂的血小板聚集率（PAG）和一氧化氮、内皮素指标；然后采用信封法随机分为辛伐他汀组和对照组，均继续口服阿司匹林，辛伐他汀组加用辛伐他汀。治疗2月后复查上述指标，观察辛伐他汀对上述指标的影响。结果对照组两次检测内皮素、一氧化氮浓度及以AA和ADP诱导的PAG，差异均无统计学意义（t分别=1.66、0.56、1.13、0.13，P均＞0.05）。治疗2月后，辛伐他汀组内皮素及以AA和ADP诱导的PAG检测值明显降低，一氧化氮浓度增高，差异均有统计学意义（t分别=14.51、6.09、5.64、15.07，P均＜0.05）；同时与对照组治疗后比较，辛伐他汀组内皮素及以AA和ADP诱导的PAG明显降低，一氧化氮浓度明显升高，差异均有统计学意义（t分别=17.48、3.39、2.05、11.41，P均＜0.05）。结论辛伐他汀可改善高血压病合并高脂血症及阿司匹林低生化反应患者血管内皮功能，可能同时改善阿司匹林抗血小板聚集功能。
目的探討辛伐他汀對高血壓病閤併高脂血癥及阿司匹林低生化反應患者內皮功能及血小闆聚集率的影響。方法採用前瞻性隨機對照研究，口服腸溶阿司匹林片1週後，高血壓病閤併高脂血癥及阿司匹林低生化反應患者109例入選，檢測用花生四烯痠（AA）和二燐痠腺苷（ADP）作誘導劑的血小闆聚集率（PAG）和一氧化氮、內皮素指標；然後採用信封法隨機分為辛伐他汀組和對照組，均繼續口服阿司匹林，辛伐他汀組加用辛伐他汀。治療2月後複查上述指標，觀察辛伐他汀對上述指標的影響。結果對照組兩次檢測內皮素、一氧化氮濃度及以AA和ADP誘導的PAG，差異均無統計學意義（t分彆=1.66、0.56、1.13、0.13，P均＞0.05）。治療2月後，辛伐他汀組內皮素及以AA和ADP誘導的PAG檢測值明顯降低，一氧化氮濃度增高，差異均有統計學意義（t分彆=14.51、6.09、5.64、15.07，P均＜0.05）；同時與對照組治療後比較，辛伐他汀組內皮素及以AA和ADP誘導的PAG明顯降低，一氧化氮濃度明顯升高，差異均有統計學意義（t分彆=17.48、3.39、2.05、11.41，P均＜0.05）。結論辛伐他汀可改善高血壓病閤併高脂血癥及阿司匹林低生化反應患者血管內皮功能，可能同時改善阿司匹林抗血小闆聚集功能。
목적탐토신벌타정대고혈압병합병고지혈증급아사필림저생화반응환자내피공능급혈소판취집솔적영향。방법채용전첨성수궤대조연구，구복장용아사필림편1주후，고혈압병합병고지혈증급아사필림저생화반응환자109례입선，검측용화생사희산（AA）화이린산선감（ADP）작유도제적혈소판취집솔（PAG）화일양화담、내피소지표；연후채용신봉법수궤분위신벌타정조화대조조，균계속구복아사필림，신벌타정조가용신벌타정。치료2월후복사상술지표，관찰신벌타정대상술지표적영향。결과대조조량차검측내피소、일양화담농도급이AA화ADP유도적PAG，차이균무통계학의의（t분별=1.66、0.56、1.13、0.13，P균＞0.05）。치료2월후，신벌타정조내피소급이AA화ADP유도적PAG검측치명현강저，일양화담농도증고，차이균유통계학의의（t분별=14.51、6.09、5.64、15.07，P균＜0.05）；동시여대조조치료후비교，신벌타정조내피소급이AA화ADP유도적PAG명현강저，일양화담농도명현승고，차이균유통계학의의（t분별=17.48、3.39、2.05、11.41，P균＜0.05）。결론신벌타정가개선고혈압병합병고지혈증급아사필림저생화반응환자혈관내피공능，가능동시개선아사필림항혈소판취집공능。
Objective To investigate the impact of simvastatin on the endothelial function and platelet aggregation rate in patients with low aspirin biochemical responsiveness. Methods After taking aspirin for one week, 109 cases of hyper-tensive patients combined with hyperlipidemia and low aspirin biochemical responsiveness were assigned. The blood levels of platelet aggregation rate (PAG) that induced by arachidonic acid (AA) and adenosine diphosphate (ADP), nitric oxide (NO) and endothelin (ET) were detected. Then they were randomly divided into control group and the simvastatin group. Both group continued to take aspirin while the simvastatin group were given simvastatin. After two months, these indicators were detected again. Results No change of PAG, ET and NO was observed in the control group(t=1.66,0.56,1.13,0.13, P>0.05). In the simvastatin group, concentration of ET, PAG induced by AA and ADP were significantly reduced while concentration of NO was significantly increased (t=14.51, 6.09,5.64,15.07,P<0.05). Compared with the control group, the PAG induced by ADP, ET and AA of the simvastatin group were significantly reduce while the concentration of NO was significantly increased(t=17.48,3.39,2.05,11.41,P<0.05). Conclusion Simvastatin may not only improve endothelial function in hypertensive patients combined with hyperlipidemia and low aspirin biochemical responsiveness, but also im-prove the function of aspirin anti-platelet aggregation at the same time.
