CAJ | 학술논문

细胞色素P450（cytochrome P450，CYP）基因多态性是构成药物代谢个体差异和种族差异的基础，细胞色素P4502D6（CYP2D6）是P450家族中参与肝脏代谢的主要酶类之一，它主要参与三环类抗抑郁药、抗心律失常药、抗精神病药、解热镇痛药、麻醉药、β-肾上腺素能受体阻断剂、选择性5-羟色胺再吸收抑制剂、神经镇静药以及一些抗癌药物等的代谢。研究CYP2D6基因多态性与药物代谢个体差异的相关性，有助于减轻药物不良反应，提高药物治疗效果，实施个体化给药的途径。
세포색소P450（cytochrome P450，CYP）기인다태성시구성약물대사개체차이화충족차이적기출，세포색소P4502D6（CYP2D6）시P450가족중삼여간장대사적주요매류지일，타주요삼여삼배류항억욱약、항심률실상약、항정신병약、해열진통약、마취약、β-신상선소능수체조단제、선택성5-간색알재흡수억제제、신경진정약이급일사항암약물등적대사。연구CYP2D6기인다태성여약물대사개체차이적상관성，유조우감경약물불량반응，제고약물치료효과，실시개체화급약적도경。
Cytochrome P450 (CYP) gene polymorphism is the foundation of individual differences and ethnic differences in drug metabolism. CYP2D6 is an important member of CYP family that is responsible for metabolism in hepar, which mainly involved in tricyclic antidepressants, anti-arrhythmic drugs, antipsychotics, antipyretic analgesics, narcotic, β-adrenergic receptor blockers, selective serotonin reuptake inhibitors, nerve sedative and some anti-cancer drugs. To study the correlations between CYP2D6 gene polymorphisms and individual difference in drug metabolism, which can help us to find out the way how to reduce adverse drug reactions, enhance drug therapeutic effects, implement individualized dosing.