CAJ | 학술논문

目的分析支气管扩张症的临床特点及病原学分析，指导此类病人的规范性抗菌治疗，减少耐药菌的发生。方法回顾性分析我科2007年1月至2011年12月共收治的支气管扩张症急性感染期81例患者的临床资料，总结分析其临床表现、发病部位分布、病原学分布及治疗情况。结果咳嗽、咳痰、咯血和发热为支气管扩张症的常见症状。左肺上下叶、右肺中叶及下叶是常见的发病部位。革兰阴性菌感染常见，其中铜绿假单胞菌为最常见致病菌，占所有病原体的比例为34.6%，占革兰阴性菌的比例为46.6%。结论支气管扩张症患者感染加重期痰标本病原菌分布以革兰阴性菌为主，第三、四代头孢菌素及氟喹诺酮类药物可作为支气管扩张症治疗经验用药的首选，临床选择抗生素时应慎重，必要时可联合用药。
목적분석지기관확장증적림상특점급병원학분석，지도차류병인적규범성항균치료，감소내약균적발생。방법회고성분석아과2007년1월지2011년12월공수치적지기관확장증급성감염기81례환자적림상자료，총결분석기림상표현、발병부위분포、병원학분포급치료정황。결과해수、해담、각혈화발열위지기관확장증적상견증상。좌폐상하협、우폐중협급하협시상견적발병부위。혁란음성균감염상견，기중동록가단포균위최상견치병균，점소유병원체적비례위34.6%，점혁란음성균적비례위46.6%。결론지기관확장증환자감염가중기담표본병원균분포이혁란음성균위주，제삼、사대두포균소급불규낙동류약물가작위지기관확장증치료경험용약적수선，림상선택항생소시응신중，필요시가연합용약。
Objective: analyses of clinical features of bronchiectasis and the etiology involved instructions of standard antibiotic therapy for these patients, and lessening the occurrence of drug-fast bacteria. Methods: retrospective analyses of clinical data of 81 bronchiectasis patients during the acute infection from January, 2007 to December, 2011 in our clinic, summing up their clinical features, distribution of tumor location, and distribution of etiology and treatment. Results:cough, expectoration, hemoptysis and fever are common symptoms of bronchiectasis. Upper and lower lobe of left lung, middle and lower lobe of right lung are common tumor location. The infections of Gram-negative bacteria are commonly seen; pseudomonas aeruginosa can be viewed as common pathogen, taking the proportion of 34.6% in all pathogen and the proportion of 46.6% in Gram-negative bacteria. Conclusion: A Gram-negative bacterium is the main bacterial distribution of exacerbation of sputum specimens from bronchiectasis patients; Third and Fourth-Generation-Cephalosporin and fluoroquinolones are best choices for bronchiectasis therapy; special care should be taken for choice of antibiotics; drug combination is available if necessary.