CAJ | 학술논문

钯催化有机卤代烃参与的对碳杂原子重键化合物的1,2-加成反应，可以有效避免传统Grignard反应、Barbier反应中活泼有机金属试剂的制备，简化合成操作并提高底物官能团的适应性，具有良好的应用前景。本文对近年来该类反应在合成化学中的发展进行了综述。
파최화유궤서대경삼여적대탄잡원자중건화합물적1,2-가성반응，가이유효피면전통Grignard반응、Barbier반응중활발유궤금속시제적제비，간화합성조작병제고저물관능단적괄응성，구유량호적응용전경。본문대근년래해류반응재합성화학중적발전진행료종술。
Palladium-catalyzed 1,2-addition reaction of organohalide to carbon-heteroatom multibond effectively avoids the preparation of active organometallic reagent (commonly used in the traditional Grignard, Barbier reactions), and simplifies the synthetic process and improves scope of the substrate bearing different functional groups. This review summarized recent advances of this 1,2-addition reaction in organic chemistry.