中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2013年
9期
40-43
,共4页
冠心病%高血压%动脉粥样硬化,同型半胱氨酸%一氧化氮
冠心病%高血壓%動脈粥樣硬化,同型半胱氨痠%一氧化氮
관심병%고혈압%동맥죽양경화,동형반광안산%일양화담
Coronary artery disease%Essential hypertension%Atherosclerosis%Homocysteine nitric oxide%Nitric oxide
目的探讨高血压及伴冠心病的动脉粥样硬化患者血浆同型半胱氨酸（Hcy）、一氧化氮（NO）变化的特性。方法对高血压或伴冠心病患者通过颈动脉超声及冠状动脉造影明确存在动脉粥样硬化的患者211例，冠心病/高血压病患者99例，高血压122例，进行Hcy、NO及超敏C反应蛋白（hs-CRP）测定。结果冠心病患者血浆Hcy浓度为（18.57±7.47）μmol/L，明显高于单纯高血压组（14.53±10.58）μmol/L（P＜0.01），hs-CRP水平（3.73±3.89）mg/L，明显高于高血压组（2.38±2.86）mg/L，P＜0.05。冠心病患者血清NO浓度为（51.15±18.78）μmol/L，显著低于高血压组（70.39±41.55）μmol/L，P＜0.001。结论 Hcy、NO及hs-CRP的异常与动脉粥样硬化的发展有关，冠心病冠状动脉粥样硬化伴颈动脉粥样硬化多部位血管病变患者的Hcy与NO水平反比的程度以及hs-CRP明显高于高血压伴颈动脉病变的单部位的患者，提示Hcy水平及炎症参与了血管损伤的过程。
目的探討高血壓及伴冠心病的動脈粥樣硬化患者血漿同型半胱氨痠（Hcy）、一氧化氮（NO）變化的特性。方法對高血壓或伴冠心病患者通過頸動脈超聲及冠狀動脈造影明確存在動脈粥樣硬化的患者211例，冠心病/高血壓病患者99例，高血壓122例，進行Hcy、NO及超敏C反應蛋白（hs-CRP）測定。結果冠心病患者血漿Hcy濃度為（18.57±7.47）μmol/L，明顯高于單純高血壓組（14.53±10.58）μmol/L（P＜0.01），hs-CRP水平（3.73±3.89）mg/L，明顯高于高血壓組（2.38±2.86）mg/L，P＜0.05。冠心病患者血清NO濃度為（51.15±18.78）μmol/L，顯著低于高血壓組（70.39±41.55）μmol/L，P＜0.001。結論 Hcy、NO及hs-CRP的異常與動脈粥樣硬化的髮展有關，冠心病冠狀動脈粥樣硬化伴頸動脈粥樣硬化多部位血管病變患者的Hcy與NO水平反比的程度以及hs-CRP明顯高于高血壓伴頸動脈病變的單部位的患者，提示Hcy水平及炎癥參與瞭血管損傷的過程。
목적탐토고혈압급반관심병적동맥죽양경화환자혈장동형반광안산（Hcy）、일양화담（NO）변화적특성。방법대고혈압혹반관심병환자통과경동맥초성급관상동맥조영명학존재동맥죽양경화적환자211례，관심병/고혈압병환자99례，고혈압122례，진행Hcy、NO급초민C반응단백（hs-CRP）측정。결과관심병환자혈장Hcy농도위（18.57±7.47）μmol/L，명현고우단순고혈압조（14.53±10.58）μmol/L（P＜0.01），hs-CRP수평（3.73±3.89）mg/L，명현고우고혈압조（2.38±2.86）mg/L，P＜0.05。관심병환자혈청NO농도위（51.15±18.78）μmol/L，현저저우고혈압조（70.39±41.55）μmol/L，P＜0.001。결론 Hcy、NO급hs-CRP적이상여동맥죽양경화적발전유관，관심병관상동맥죽양경화반경동맥죽양경화다부위혈관병변환자적Hcy여NO수평반비적정도이급hs-CRP명현고우고혈압반경동맥병변적단부위적환자，제시Hcy수평급염증삼여료혈관손상적과정。
Objective To explore the serum level of homocysteine (Hcy), nitric oxide (NO) in patients with or without coronary heart diseases and the relationship between vasoactive substances and carotid atherosclerosis. Methods Serum Hcy, NO and hs CRP levels were measured in 211 hospitalized patients, among them 99 with coronary heart disease (diagnosed by coronary angiography) and 122 with essential hypertension. Results Serum Hcy concentration was (18.57±7.47) μmol/L in CHD patients, which was higher signiifcantly than that in hypertensive patients (14.53±10.58)μmol/L (P < 0.01). Serum NO concentration in CHD patients was lower signiifcantly than that in simple hypertension patients (P<0.001), the mean level was (51.15±18.78) μmol/L and (70.39±41.55) μmol/L respectively. 94.1% patients complicated with carotid artery lesions in CHD group, which was higher signiifcantly than that in hypertension group, P < 0.001. Conclusion High homocysteinemia is closely related to the occurrence of coronary heart disease. Hcy levels was inversely proportional to NO levels, which relfecting the obvious relevance of Hcy levels to the severity of vascular injury. Carotid artery lesions and coronary artery disease was positively correlated. The simple, non-invasive and reproducible method of carotid artery ultrasound is expected to become the window of observing the coronary artery diseases.
