CAJ | 학술논문

心力衰竭是多种心血管疾病的最终结局。心力衰竭时存在心脏器官水平的结构重构和细胞、离子通道分子水平的心电重构。心脏的离子通道重构最初是在病理状态下维持心功能的适应性反应，但持续存在的病理状态导致的重构本身也可以引起疾病的发生，与心力衰竭中心律失常的发生密切相关。心力衰竭时心室肌细胞多种离子通道的表达和功能发生变化，如IK1、Ito、IKs、ICa-L、IK、INaL、INa+/Ca2+等，导致心室肌细胞的静息电位和动作电位的各期均发生从细微到显著的变化，存在离子通道的重构与心肌细胞电活动的稳态调节。从整体上逆转离子通道重构，以所有离子通道的稳态调节为目标进行治疗，可能是改善心力衰竭时心电重构的关键。
심력쇠갈시다충심혈관질병적최종결국。심력쇠갈시존재심장기관수평적결구중구화세포、리자통도분자수평적심전중구。심장적리자통도중구최초시재병리상태하유지심공능적괄응성반응，단지속존재적병리상태도치적중구본신야가이인기질병적발생，여심력쇠갈중심률실상적발생밀절상관。심력쇠갈시심실기세포다충리자통도적표체화공능발생변화，여IK1、Ito、IKs、ICa-L、IK、INaL、INa+/Ca2+등，도치심실기세포적정식전위화동작전위적각기균발생종세미도현저적변화，존재리자통도적중구여심기세포전활동적은태조절。종정체상역전리자통도중구，이소유리자통도적은태조절위목표진행치료，가능시개선심력쇠갈시심전중구적관건。
Heart failure (HF) is the ifnal ending of a variety of cardiovascular diseases. There is not only the structural remodeling in heart but also electrical remodeling in the ion channels. Remodeling of the ion channels, which is adaptive response to preserve cardiac function under pathological stress initially, leads to dysfunction itself if the stress is maintained and it is closely related to arrhythmias in HF. Many ion channels of ventricular myocytes change their expressions and functions in HF, such as IK1, Ito, IKs, ICa-L, IK, INaL, INa+/Ca2+, and so on. The resting potential and every period of action potential have their remodeling and homeostasis regulation of ion channels in ventricular myocytes. It provides us a new perspective that reversing the remodeling of ion channels as a whole and regulate the homeostasis of all ion channels is the key to improve the electrical remodeling in HF.