CAJ | 학술논문

目的：：探讨Nusap1在肝癌中的表达，分析其与临床病理特征及预后的关系。方法：采用免疫组织化学SP法检测61例肝癌标本中Nusap1的表达情况，并结合临床资料分析Nusap1表达高低与患者的临床病理特征及预后的关系。结果：Nusap1在肝癌组织中的高表达率为54.1%(33/61)，而在非癌组织中的高表达率为21.3%(13/61)，差异有统计学意义(P<0.01)。在肝癌组中，Nusap1高表达与肿瘤大小、病理分化、淋巴结转移、门脉癌栓、肝硬化、早期复发等密切相关(P<0.05)，与患者性别、年龄、肿瘤数目、包膜、AFP、TNM分期等均无关(P>0.05)；33例Nusap1蛋白高表达者及28例低表达者6个月及12个月无瘤生存率分别为33.3%(11/33)，17.9%(5/33)及89.3%(25/28)，53.6%(15/28)(P<0.005)。结论：Nusap1在肝癌组织中存在过表达，检测其表达水平对肝癌患者术后转移复发及预后的判断有一定的指导意义。
목적：：탐토Nusap1재간암중적표체，분석기여림상병리특정급예후적관계。방법：채용면역조직화학SP법검측61례간암표본중Nusap1적표체정황，병결합림상자료분석Nusap1표체고저여환자적림상병리특정급예후적관계。결과：Nusap1재간암조직중적고표체솔위54.1%(33/61)，이재비암조직중적고표체솔위21.3%(13/61)，차이유통계학의의(P<0.01)。재간암조중，Nusap1고표체여종류대소、병리분화、림파결전이、문맥암전、간경화、조기복발등밀절상관(P<0.05)，여환자성별、년령、종류수목、포막、AFP、TNM분기등균무관(P>0.05)；33례Nusap1단백고표체자급28례저표체자6개월급12개월무류생존솔분별위33.3%(11/33)，17.9%(5/33)급89.3%(25/28)，53.6%(15/28)(P<0.005)。결론：Nusap1재간암조직중존재과표체，검측기표체수평대간암환자술후전이복발급예후적판단유일정적지도의의。
Objective:To investigate the expression and clinical significance of Nusap1 in hepatical carcinoma. Methods:The expression of Nusap1 protein in 61 specimens of hepatical carcinoma was examined by immunohistochemistry. Based on the levels of Nusap1 expression, the 61 specimens were divided into a high Nusap1 expression group and a low Nusap1 expression group. The correlation between Nusap1 expression with clinicopathologic features and prognosis of hepatical carcinoma was analyzed. Results:TherateofhighNusap1expressionwas54.1%inhepaticalcarcinoma.TherateofhighNusap1 expression was 21.3%in noncarcinoma, with signiifcant difference between the 2 groups (P<0.01).Nusap1 overexpression had signiifcant correlation with histological differentiation, tumor size, liver cirrhosis,lymphaticmetastasis,tumorthrombiandearlyrecurrence(P<0.05),butnotwithsex,age,AFP level,tumornumber,TNMclassificationandtumorencapsulation(P>0.05).Survivalanalysissuggested thatthe6monthand12monthnoncarcinomasurvivalratewassignificantlylowerinthehighNusap1 expression group [33.3%(11/33), 17.9%(5/33)] than that in the low Nusap1 expression group [89.3%(25/28), 53.6%(15/28);P<0.005]. Conclusion:Nusap1 is overexpressed in hepatical carcinoma and is a valuable prognostic factor for hepatical carcinoma.