CAJ | 학술논문

目的：探讨2型糖尿病(T2DM)患者葡萄糖耐量试验(OGTT,口服葡萄糖75 g)后胰高糖素样肽1(GLP-1)水平与血糖、胰岛β细胞功能、胰岛素抵抗的关系。方法 T2DM 患者35例及健康对照组30例均禁食12小时以上后行 OGTT,采集0(即空腹)、0.5、2小时血样,分别测定血浆葡萄糖、胰岛素、GLP-1浓度、糖化血红蛋白(HbA1 c)水平。结果 T2DM 患者的0、0.5、2小时血糖、空腹胰岛素及 HbA1 c 明显高于对照组(P <0.05),而T2DM 患者0.5小时胰岛素及2小时 GLP-1水平明显低于对照组(P <0.05),餐后2小时胰岛素水平及0、0.5小时GLP-1水平与对照组比较差异无统计学意义(P >0.05)。结论餐后 GLP-1水平的上升与进餐刺激有关；T2DM 患者口服葡萄糖后 GLP-1的分泌水平可能与血糖水平、胰岛功能、胰岛素抵抗相关。
목적：탐토2형당뇨병(T2DM)환자포도당내량시험(OGTT,구복포도당75 g)후이고당소양태1(GLP-1)수평여혈당、이도β세포공능、이도소저항적관계。방법 T2DM 환자35례급건강대조조30례균금식12소시이상후행 OGTT,채집0(즉공복)、0.5、2소시혈양,분별측정혈장포도당、이도소、GLP-1농도、당화혈홍단백(HbA1 c)수평。결과 T2DM 환자적0、0.5、2소시혈당、공복이도소급 HbA1 c 명현고우대조조(P <0.05),이T2DM 환자0.5소시이도소급2소시 GLP-1수평명현저우대조조(P <0.05),찬후2소시이도소수평급0、0.5소시GLP-1수평여대조조비교차이무통계학의의(P >0.05)。결론찬후 GLP-1수평적상승여진찬자격유관；T2DM 환자구복포도당후 GLP-1적분비수평가능여혈당수평、이도공능、이도소저항상관。
Objective To investigate the relationship of glucagon-like peptide 1 (GLP-1 )level with blood glucose,β-cell function,insulin resistance after glucose tolerance test(OGTT,oral glucose,75 g)in type 2 diabetes mellitus(T2DM)patients.Methods Thirty-five T2DM patients and 30 healthy subjects(control group)who had fasted for 12 hours underwent OGTT,then,0,0.5,2 hours of blood sample were collected,the plasma glucose,insulin,GLP-1,glycosylated hemoglobin(HbA1 c)were measured.Results 0 hour,0.5 hour,2 hour glucose and 0 hour insulin, HbA1 c levels of T2DM group were significantly higher compared with those of healthy control group(P <0.05),but 0.5 hour insulin and 2 hour GLP-1 levels of T2DM group were significantly lower(P <0.05 ),2 hour insulin and 0 hour,0.5 hour GLP-1 levels between two groups showed no significant difference (P > 0.05 ).Conclusion Postprandial GLP-1 rise relates with meal stimulation GLP-1 level may relate with blood glucose,islet function and insulin resistance.