新疆医科大学学报
新疆醫科大學學報
신강의과대학학보
JOURNAL OF XINJIANG MEDICAL UNIVERSITY
2013年
10期
1509-1514
,共6页
阿力木江·苏甫尔%比力克孜·玉素甫%阿不都吉力力·买买提
阿力木江·囌甫爾%比力剋孜·玉素甫%阿不都吉力力·買買提
아력목강·소보이%비력극자·옥소보%아불도길력력·매매제
颞下颌关节功能紊乱病%透明质酸钠%糖皮质激素%系统评价
顳下頜關節功能紊亂病%透明質痠鈉%糖皮質激素%繫統評價
섭하합관절공능문란병%투명질산납%당피질격소%계통평개
hyaluronate%temporomandibular disorders%glucocorticoids%systematic review
目的系统评价透明质酸钠(HS)与激素(CO)治疗颞下颌关节功能紊乱(TMD)的临床疗效及不良反应。方法检索Cochrane图书馆临床对照资料、Medline、Embase、中国生物医学文献数据库、中国循证医学数据库、维普数据库等。2位评价者独立使用Cochrane协作网推荐的标准对纳入文献进行偏倚风险评价并提取数据。运用 Revman 5.0.14软件进行 Meta分析。结果最终纳入研究的文献为5篇。(1)综合指标短期内的症状改善及体征改善差异无统计学意义(P >0.05)。(2)单一临床指标分析改善短期临床表现:下颌运动疼痛症状、最大张口度、关节区压痛、综合效应两组差异无统计学意义(P >0.05)。(3)特殊指标定性分析(高分辨CT评估骨组织改变):两组破坏性及修复性骨改变差异无统计学意义。(4)注射后不良反应疼痛较强烈的进行合并分析:显示两组差异无统计学意义(P >0.05)。结论 HS与CO进行颞下颌关节上腔注射治疗TMD短期内疗效及不良反应无明显差异。HS不良反应轻微且暂时,但疼痛较重的病例CO有一定的效果。
目的繫統評價透明質痠鈉(HS)與激素(CO)治療顳下頜關節功能紊亂(TMD)的臨床療效及不良反應。方法檢索Cochrane圖書館臨床對照資料、Medline、Embase、中國生物醫學文獻數據庫、中國循證醫學數據庫、維普數據庫等。2位評價者獨立使用Cochrane協作網推薦的標準對納入文獻進行偏倚風險評價併提取數據。運用 Revman 5.0.14軟件進行 Meta分析。結果最終納入研究的文獻為5篇。(1)綜閤指標短期內的癥狀改善及體徵改善差異無統計學意義(P >0.05)。(2)單一臨床指標分析改善短期臨床錶現:下頜運動疼痛癥狀、最大張口度、關節區壓痛、綜閤效應兩組差異無統計學意義(P >0.05)。(3)特殊指標定性分析(高分辨CT評估骨組織改變):兩組破壞性及脩複性骨改變差異無統計學意義。(4)註射後不良反應疼痛較彊烈的進行閤併分析:顯示兩組差異無統計學意義(P >0.05)。結論 HS與CO進行顳下頜關節上腔註射治療TMD短期內療效及不良反應無明顯差異。HS不良反應輕微且暫時,但疼痛較重的病例CO有一定的效果。
목적계통평개투명질산납(HS)여격소(CO)치료섭하합관절공능문란(TMD)적림상료효급불량반응。방법검색Cochrane도서관림상대조자료、Medline、Embase、중국생물의학문헌수거고、중국순증의학수거고、유보수거고등。2위평개자독립사용Cochrane협작망추천적표준대납입문헌진행편의풍험평개병제취수거。운용 Revman 5.0.14연건진행 Meta분석。결과최종납입연구적문헌위5편。(1)종합지표단기내적증상개선급체정개선차이무통계학의의(P >0.05)。(2)단일림상지표분석개선단기림상표현:하합운동동통증상、최대장구도、관절구압통、종합효응량조차이무통계학의의(P >0.05)。(3)특수지표정성분석(고분변CT평고골조직개변):량조파배성급수복성골개변차이무통계학의의。(4)주사후불량반응동통교강렬적진행합병분석:현시량조차이무통계학의의(P >0.05)。결론 HS여CO진행섭하합관절상강주사치료TMD단기내료효급불량반응무명현차이。HS불량반응경미차잠시,단동통교중적병례CO유일정적효과。
Objective Compare the efficacy and the complications of intraarticular TMJ injections of hyalu-ronate(HS)and glucocorticoids(CO).Methods Data sources Cochrane Library CENTRAL/CCTR data base,EMbase,Medline,PubMed,Chinese literature databases such as CNKI and Chinese Evidence Based Medicine.We selected 5 randomised controlled studies.Two independent reviewers undertook data extrac-tion.Risk of bias assessment with Cochrane Collaborations tool,Meta analysis was done with Revman 5.0.14.Results Short term effect comparison on improvement symptoms of TMD and Short term effect on improvement of clinical signs;There was no statistically significant difference between the groups (P>0.05).Evaluation of the treatment effects by single clinical variables such as Relief of TMJ pain when mandibular movment,maximum Mouth opening,TMJ tenderness.no statistically significant difference between the two groups (P >0.05).Adverse reactions;Mild and transient adverse reactions at the injec-tion site were reported in the HS groups than CO group.There was no statistically significant difference between the groups in terms of high pain intensity in short term (P >0.05).Conclusion There was no statistically significant difference between the two drugs in short term on improvement TMD,even no much more different on adverse reactions.HS may suffer from only mild and transient adverse reactions;while CO had efficiency on the painful condition.However,more RCTs are needed to confirm its therapeu-tic effect.