CAJ | 학술논문

目的探讨前列腺基底细胞增生和基底细胞癌的组织形态学特征，提高前列腺病变的诊断与鉴别诊断水平。方法回顾性分析10例前列腺基底细胞增生和1例前列腺基底细胞癌病例特征，观察其形态学特征，并做基底细胞特异性标记高分子角蛋白抗体（34βΕ12）、P63蛋白及前列腺特异性抗原（PSA）免疫组织化学染色。结果基底细胞增生镜下表现为基底细胞密度增加，层次增多，可环绕腺腔增生多层，或在腺泡一侧呈小灶状、片状增生，增生也可呈实性巢或筛状结构，几种形态常混合存在。增生的基底细胞无异型性及核分裂像，核仁不易见。基底细胞癌镜下呈不规则实性团片状，在纤维结缔组织中呈浸润性生长，细胞核染色深，细胞核浆比大，异型性明显，核分裂像易见。结论基底细胞增生镜下形态多样，与基底细胞癌鉴别主要依赖组织形态学特征，免疫组织化学可以辅助鉴别诊断。
목적탐토전렬선기저세포증생화기저세포암적조직형태학특정，제고전렬선병변적진단여감별진단수평。방법회고성분석10례전렬선기저세포증생화1례전렬선기저세포암병례특정，관찰기형태학특정，병주기저세포특이성표기고분자각단백항체（34βΕ12）、P63단백급전렬선특이성항원（PSA）면역조직화학염색。결과기저세포증생경하표현위기저세포밀도증가，층차증다，가배요선강증생다층，혹재선포일측정소조상、편상증생，증생야가정실성소혹사상결구，궤충형태상혼합존재。증생적기저세포무이형성급핵분렬상，핵인불역견。기저세포암경하정불규칙실성단편상，재섬유결체조직중정침윤성생장，세포핵염색심，세포핵장비대，이형성명현，핵분렬상역견。결론기저세포증생경하형태다양，여기저세포암감별주요의뢰조직형태학특정，면역조직화학가이보조감별진단。
Objective To recognize the morphologic features of prostatic basal cell hyperplasia(BCH)and basal cell carcinoma in order to facilitate the diagnosis and differential diagnosis of prostate lesions. Methods 10 cases of BCH and a case of basal cell carcinoma of the prostate were reviewed;their morpho-logic varieties were carefully observed and immunoperoxidase stains for basal cell specific antibody 34βE12,P63 and PSA were also performed.Results The morphology of prostatic BCH are shown by the increased density,forming double layer-glandlike,or layers,solid,or cribriform often with admixed growth patterns.The hyperplasia basal cells have not atypia and mitotic figures,nucleoli.Basal cell carci-noma consisted of solid sheets and nests,and infiltrated to fiber tissues,which had large nucleoli,mitoses were frequently seen.Conclusion The microscopic features of BCH are of varieties,which should be dif-ferentiated with basal cell carcinoma.The diagnosis of BCH mainly relies on its specific morphologic fea-tures,and immunoperoxidase stains is helpful in diagnosis and differential diagnosis.