CAJ | 학술논문

目的：研究多囊卵巢综合征（PCOS）不孕患者血清 Apelin 水平的变化及其与胰岛素抵抗（IR）的关系。方法：选择2011年1月至2012年6月间首次来我院就诊的98例PCOS不孕患者及72例非PCOS不孕患者，分别分为PCOS组和非PCOS组。分别比较两组患者的体重指数（BMI）、血清Apelin、血糖、胰岛素、稳态模型胰岛素抵抗指数（HOMA-IR）间的相互关系。血清Apelin采用ELISA法测定，空腹血浆葡萄糖（FPG）采用葡萄糖氧化酶法测定，空腹胰岛素（FIns）采用化学发光法测定。结果：PCOS 组血清Apelin 水平（μg/L）明显高于非PCOS组（3．28±1．24 vs．1．94±0．78， P＜0．05）。 PCOS 组的HOMA-IR 高于非PCOS 组（3．84±1．23 vs．2．14±0．77， P＜0．05）； Person 相关分析表明， PCOS 组血清 Apelin 水平与 HOMA-IR 相关（r＝0．65， P＜0．01）。结论：PCOS不孕患者血清Apelin水平升高，并且其升高与IR 密切相关。提示Apelin可能参与PCOS不孕患者IR的发生发展。
목적：연구다낭란소종합정（PCOS）불잉환자혈청 Apelin 수평적변화급기여이도소저항（IR）적관계。방법：선택2011년1월지2012년6월간수차래아원취진적98례PCOS불잉환자급72례비PCOS불잉환자，분별분위PCOS조화비PCOS조。분별비교량조환자적체중지수（BMI）、혈청Apelin、혈당、이도소、은태모형이도소저항지수（HOMA-IR）간적상호관계。혈청Apelin채용ELISA법측정，공복혈장포도당（FPG）채용포도당양화매법측정，공복이도소（FIns）채용화학발광법측정。결과：PCOS 조혈청Apelin 수평（μg/L）명현고우비PCOS조（3．28±1．24 vs．1．94±0．78， P＜0．05）。 PCOS 조적HOMA-IR 고우비PCOS 조（3．84±1．23 vs．2．14±0．77， P＜0．05）； Person 상관분석표명， PCOS 조혈청 Apelin 수평여 HOMA-IR 상관（r＝0．65， P＜0．01）。결론：PCOS불잉환자혈청Apelin수평승고，병차기승고여IR 밀절상관。제시Apelin가능삼여PCOS불잉환자IR적발생발전。
Objective To explore the change of serum Apelin level and its relationship with insulin resistance (IR) in infertility patients with polycystic ovarian syndrome (PCOS). Methods Ninety-eight infertility patients with PCOS (PCOS group) and 72 infertility patients without PCOS (non-PCOS group) visiting our hospital for the first time from January 2011 to June 2012 were selected. The BMI , serum Apelin level (detected by ELISA), fasting blood glucose (FPG, detected by glucose oxidase method), fasting insulin (Fins, detected by chemiluminescence), and homeostasis model assessment of insulin resistance index (HOMA-IR) of the two groups were detected. Results The serum Apelin level and HOMA-IR in PCOS patients were higher than those in non-PCOS patients (3.28 ± 1.24 vs. 1.94 ± 0.78, P < 0.05; 3.84 ± 1.23 vs. 2.14 ± 0.77,P < 0.05). Pearson correlation analysis showed that serum Apelin level was positively correlated with HOMA-IR in PCOS patients (r=0.65, P<0.01). Conclusions The serum Apelin level in infertility patients with PCOS increased evidently, and was positively correlated with HOMA-IR; which indicated that Apelin may involve in the development of IR in infertility patients with PCOS.