CAJ | 학술논문

目的探讨富含亮氨酸重复序列免疫球蛋白样蛋白1(LRIGl)在垂体瘤中的表达及意义.方法应用免疫组织化学链菌素抗生物素蛋白-过氧化物酶(SP)法检测74例垂体瘤、20例正常脑组织中LRIG1的表达,分析其表达与患者预后的关系.结果 LRIG1在正常脑组织中的阳性表达率为100.0％,明显高于垂体瘤中的表达(54.1％),差异有统计学意义(P＜0.05).同时,LRIG1在非侵袭性垂体瘤中的阳性表达率为66.7％,明显高于在侵袭性垂体瘤中的表达(20.0％).Kaplan-Meier生存分析表明LRIG1及垂体瘤类型与患者的预后明显相关(P＜0.05).Cox多因素生存分析表明LRIGI可作为患者预后评估的独立因素.结论 LRIG1参与了垂体瘤的发生及发展,低表达患者预后较差.
목적 탐토부함량안산중복서렬면역구단백양단백1(LRIGl)재수체류중적표체급의의.방법 응용면역조직화학련균소항생물소단백-과양화물매(SP)법검측74례수체류、20례정상뇌조직중LRIG1적표체,분석기표체여환자예후적관계.결과 LRIG1재정상뇌조직중적양성표체솔위100.0％,명현고우수체류중적표체(54.1％),차이유통계학의의(P＜0.05).동시,LRIG1재비침습성수체류중적양성표체솔위66.7％,명현고우재침습성수체류중적표체(20.0％).Kaplan-Meier생존분석표명LRIG1급수체류류형여환자적예후명현상관(P＜0.05).Cox다인소생존분석표명LRIGI가작위환자예후평고적독립인소.결론 LRIG1삼여료수체류적발생급발전,저표체환자예후교차.
Objective To investigate the expression and prognostic significance of leucine-rich repeats and immunoglobulin like domains 1 (LRIG1) in pituitary adenomas.Methods Immunohistochemical streptavidin avidin-peroxidase (SP) method was used to detect the expression of LRIG1 in 74 cases of pituitary adenomas tissues and 20 cases of normal brain tissues,and the relationship between LRIG1 expression and patient prognosis was analyzed.Results The positive expression rates of LRIG1 in normal brain tissue and pituitary adenomas were 100.0％ and 54.1 ％,respectively,with a significant difference (P ＜ 0.05).Meanwhile,the positive rates of LRIG1 expression in non-invasive pituitary adenomas was 66.7％,which is significantly higher than that in invasive pituitary adenomas (20.0％).Kaplan-Meier survival analysis showed that LRIG1 and tumor type was associated with patients' prognosis (P ＜ 0.05).Cox multivariate survival analysis showed LRIG1 could be as independent prognostic factor.Conclusion LRIG1 is involved in the formation and development of pituitary adenomas,and patients with low expression of LRIG1 have poorer prognosis.