CAJ | 학술논문

目的了解白细胞介素17(IL-17)、白细胞介素23 (IL-23)与脑梗死患者颈动脉硬化的相关性.方法 2010年6月至2012年6月收集的脑梗死患者125例为研究对象.所有患者行颈动脉超声检查及血清IL-17及IL-23检查.根据颈动脉超声检查是否检出斑块,分为颈动脉硬化组(86例)与非颈动脉硬化组(39例).颈动脉硬化的患者按其斑块性质进行分组,可分为软斑块组(35例)、硬斑块组(21例)、混合性斑块组(30例)；颈动脉硬化脑梗死患者的斑块采用半定量法,按严重程度分组,分为Ⅰ级(29例)、Ⅱ级(43例)、Ⅲ级(14例).结果颈动脉硬化组与非颈动脉硬化组IL-17和IL-23比较,差异均有统计学意义[IL-17:(31.42±8.73) μg/L与(22.81±6.52) μg/L,t=5.15,P＜0.01；IL-23:(21.79±9.34) μg/L与(14.33±6.21) μg/L,t=4.99,P＜0.01].软斑块、硬斑块、混合性斑块组IL-17和IL-23比较,差异均有统计学意义(F值分别为10.181、3.835,P均＜0.05),且软斑块组和混合性斑块组患者血清IL-17表达高于硬斑块组(P =0.001；P =0.007),软斑块组患者血清IL-23表达高于混合性斑块组和硬斑块组(P =0.017;P =0.045).按斑块严重程度所分Ⅰ、Ⅱ、Ⅲ级组IL-17和IL-23比较,差异均有统计学意义(F值分别为41.046、3.739,P均＜0.05),且Ⅱ、Ⅲ级与Ⅰ组比较差异均有统计学意义(P＜0.01,P＜0.05),并存在相关性(r=0.892,P=0.000;r =0.420,P=0.041).结论 IL-17和IL-23参与动脉硬化的发生、发展,早期发现并干预对预防脑梗死的发生有一定的作用.
목적 료해백세포개소17(IL-17)、백세포개소23 (IL-23)여뇌경사환자경동맥경화적상관성.방법 2010년6월지2012년6월수집적뇌경사환자125례위연구대상.소유환자행경동맥초성검사급혈청IL-17급IL-23검사.근거경동맥초성검사시부검출반괴,분위경동맥경화조(86례)여비경동맥경화조(39례).경동맥경화적환자안기반괴성질진행분조,가분위연반괴조(35례)、경반괴조(21례)、혼합성반괴조(30례)；경동맥경화뇌경사환자적반괴채용반정량법,안엄중정도분조,분위Ⅰ급(29례)、Ⅱ급(43례)、Ⅲ급(14례).결과 경동맥경화조여비경동맥경화조IL-17화IL-23비교,차이균유통계학의의[IL-17:(31.42±8.73) μg/L여(22.81±6.52) μg/L,t=5.15,P＜0.01；IL-23:(21.79±9.34) μg/L여(14.33±6.21) μg/L,t=4.99,P＜0.01].연반괴、경반괴、혼합성반괴조IL-17화IL-23비교,차이균유통계학의의(F치분별위10.181、3.835,P균＜0.05),차연반괴조화혼합성반괴조환자혈청IL-17표체고우경반괴조(P =0.001；P =0.007),연반괴조환자혈청IL-23표체고우혼합성반괴조화경반괴조(P =0.017;P =0.045).안반괴엄중정도소분Ⅰ、Ⅱ、Ⅲ급조IL-17화IL-23비교,차이균유통계학의의(F치분별위41.046、3.739,P균＜0.05),차Ⅱ、Ⅲ급여Ⅰ조비교차이균유통계학의의(P＜0.01,P＜0.05),병존재상관성(r=0.892,P=0.000;r =0.420,P=0.041).결론 IL-17화IL-23삼여동맥경화적발생、발전,조기발현병간예대예방뇌경사적발생유일정적작용.
Objective To investigate the relationship between the interleukin-17 (IL-17),interleukin23 (IL-23) and carotid artery sclerosis in patients with cerebral infarction.Methods One hundred and twentyfive cerebral infarction patients in the first affiliated hospital of Shantou University medical college from June 2010 to June 2012 were recruited.All the subjects were examined with carotid ultrasonography.According to the results of carotid ultrasonography,all patients were divided into carotid atherosclerosis group(86 cases) and non carotid atherosclerosis group(39 cases).Patients with carotid atherosclerosis were divided into soft plaque group (35 cases),hard plaque group (21 cases),mixed plaque group (30 cases) based on plaque feature.Carotid atherosclerosis patients with cerebral infarction plaque determined by semi-quantitative method were grouped into Ⅰ grade(29 cases),Ⅱ grade (43 cases),Ⅲ grade (14 cases) according to the severity atherosclerosis.Serum levels of IL-17 and IL-23 were measured.Results The levels of IL-17 and IL-23 in patients with carotid atherosclerosis group were (31.42 ± 8.73) μg/L and(21.79 ± 9.34) μg/L,higher than that of non-carotid atherosclerosis group((22.81 ±6.52) μg/L,t =5.15,P ＜0.01 ; (14.33 ±6.21) μg/L,t =4.99,P ＜0.01).The IL-17 and IL-23 levels in patients with soft plaque,hard plaque and mixed plaque group were significant different (F =10.181,3.835,P ＜0.05).Serum IL-17 in soft plaque and mixed plaque expression group was higher than that of hard plaque group (P =0.001,P=0.007).IL-23 level in soft plaque group was higher than mixed plaque and hard plaque groups(P =0.017;P =0.045).The IL-17 and IL-23 levels in Ⅰ,Ⅱ,Ⅲ level group were markedly different (F =41.046,3.739 ; P ＜ 0.05),and there was significant difference between Ⅱ,Ⅲ and Ⅰ group(P ＜0.01,P ＜0.05).The correlation between IL-17 and IL-23 levels in Ⅰ,Ⅱ,Ⅲ level group were 0.892 and 0.420 (P =0.000 ; P =0.041).Conclusion IL-17 and IL-23 play important roles in the pathologic progress of artery sclerosis and are helpful for early diagnosis of the disease.