CAJ | 학술논문

目的：观察比较多巴胺和去甲肾上腺素治疗脓毒症休克的临床复苏效果。方法选择2011年6月至2013年6月于我院ICU住院的脓毒症休克患者50例。这些患者均经过积极的体液复苏但仍存在低血压需要使用血管活性药物升压。根据就诊前后随机分为两组，每组25例，治疗组用去甲肾上腺素升压，对照组用多巴胺维持血压，观察两组复苏效果。结果治疗组复苏率达80％，对照组为60％，组间比较差异具有统计学意义（ P＜0．05）。观察2组12h、24h的乳酸清除率，分别比较，治疗组均高于对照组，差异具有统计学意义（P＜0．05）。结论多巴胺和去甲肾上腺素均一定程度上能够复苏脓毒症休克，但去甲肾上腺素效果更理想，且能够更好的清除乳酸，提高乳酸清除率，临床上值得进一步研究应用。
목적：관찰비교다파알화거갑신상선소치료농독증휴극적림상복소효과。방법선택2011년6월지2013년6월우아원ICU주원적농독증휴극환자50례。저사환자균경과적겁적체액복소단잉존재저혈압수요사용혈관활성약물승압。근거취진전후수궤분위량조，매조25례，치료조용거갑신상선소승압，대조조용다파알유지혈압，관찰량조복소효과。결과치료조복소솔체80％，대조조위60％，조간비교차이구유통계학의의（ P＜0．05）。관찰2조12h、24h적유산청제솔，분별비교，치료조균고우대조조，차이구유통계학의의（P＜0．05）。결론다파알화거갑신상선소균일정정도상능구복소농독증휴극，단거갑신상선소효과경이상，차능구경호적청제유산，제고유산청제솔，림상상치득진일보연구응용。
Objective To observe and compare the clinical effects of dopamine and noradrenaline for treatment of septic shock .Method 50 patients of septic shock in ICU of our hospital who still needed vasoactive agent to boost blood pressure after active fluid resuscitation .They were divided into 2 groups each with 25 cases accord-ing to visiting order.Treatment group was given noradrenaline while control group was given dopamine.Resuscitation effects of both groups were observed.Result Resusci-tation rate of treatment group was 80%and control group was 60%(P<0.05).Lactate clearances of 12h and 24h of treatment group were both higher than control group (P<0.05).Conclusion Dopamine and noradrenaline both can resuscitate septic shock to an extent,but noradrenaline was better,it can improve lactate clearance,and was worth of being further studied and applied in clinical work.