CAJ | 학술논문

目的：探讨T细胞共刺激分子B7家族成员B7-H4胃癌发病中的作用,为临床诊断、治疗胃癌提供新的靶目标.方法：应用免疫组织化学染色检测62例胃癌患者手术标本中B7-H4的表达及微血管密度.结杲：①B7-H4在胃癌组织中高表达(71.7%)；②胃癌组织中B7-H4的表达与性别、年龄、组织学类型、病理分期、细胞分化和淋巴结转移均无相关性；③B7-H4阳性标本的微血管密度为26.10±14.46/0.313 mm22,明显高于B7-H4阴性标本中的(8.63±6.33),P<0.008.结论： B7-H4可能成为胃癌诊断的新指标,拮抗胃癌中的B7-H4可能成为胃癌免疫治疗的新策略.
목적：탐토T세포공자격분자B7가족성원B7-H4위암발병중적작용,위림상진단、치료위암제공신적파목표.방법：응용면역조직화학염색검측62례위암환자수술표본중B7-H4적표체급미혈관밀도.결고：①B7-H4재위암조직중고표체(71.7%)；②위암조직중B7-H4적표체여성별、년령、조직학류형、병리분기、세포분화화림파결전이균무상관성；③B7-H4양성표본적미혈관밀도위26.10±14.46/0.313 mm22,명현고우B7-H4음성표본중적(8.63±6.33),P<0.008.결론： B7-H4가능성위위암진단적신지표,길항위암중적B7-H4가능성위위암면역치료적신책략.
Objective:To investigate the role of B7-H4 in the development of gastric cancer(GC).Method:The expression of B7-H4 and microvessel density(MVD) in 60 excised gastric tumors were evaluated immunohistochemiscally.Results:B7-H4 was high expressed(71.7%)in gastric cancer. However, significantly fewer microvessel density was identified in B7-H4 negative tumor specimens than in B7-H4-positive tumor specimens. Conclusion:B7-H4 may be a new marker of diagnosis for gastric cancer;The blockade of B7-H4 in gastric cancer might be one strategy to pursue for future immunotherapy in gastric cancer.