中国保健营养（中旬刊）
中國保健營養（中旬刊）
중국보건영양（중순간）
China Hwalth Care & nutrition
2013年
2期
220-221
,共2页
凋亡抑制蛋白%Smac%食管癌%Caspase-3%免疫组化
凋亡抑製蛋白%Smac%食管癌%Caspase-3%免疫組化
조망억제단백%Smac%식관암%Caspase-3%면역조화
Smac%esophageal carcinoma%Caspase-3
目的：探讨Smac在食管癌组织中的表达及其与Caspase-3之间的关系.方法：采用免疫组织化学S-P法检测Smac和Caspase-3在食管癌组织和癌旁正常食管组织中的表达情况.结果：Smac在食管癌旁正常食管组织中的表达明显高于癌组织( P<0.05).Smac表达与癌组织分化程度无关( P>0.05).Caspase-3在癌旁正常食管组织中表达明显高于癌组织( P<0.05).在食管癌组织Smac与Caspase-3表达呈正相关( P<0.05).结论：Smac在食管癌组织中异常表达，有望成为食管癌诊断和基因治疗的新靶点.Smac基因与凋亡相关基因Caspase-3的异常表达可能在食管癌癌变中起协调作用.
目的：探討Smac在食管癌組織中的錶達及其與Caspase-3之間的關繫.方法：採用免疫組織化學S-P法檢測Smac和Caspase-3在食管癌組織和癌徬正常食管組織中的錶達情況.結果：Smac在食管癌徬正常食管組織中的錶達明顯高于癌組織( P<0.05).Smac錶達與癌組織分化程度無關( P>0.05).Caspase-3在癌徬正常食管組織中錶達明顯高于癌組織( P<0.05).在食管癌組織Smac與Caspase-3錶達呈正相關( P<0.05).結論：Smac在食管癌組織中異常錶達，有望成為食管癌診斷和基因治療的新靶點.Smac基因與凋亡相關基因Caspase-3的異常錶達可能在食管癌癌變中起協調作用.
목적：탐토Smac재식관암조직중적표체급기여Caspase-3지간적관계.방법：채용면역조직화학S-P법검측Smac화Caspase-3재식관암조직화암방정상식관조직중적표체정황.결과：Smac재식관암방정상식관조직중적표체명현고우암조직( P<0.05).Smac표체여암조직분화정도무관( P>0.05).Caspase-3재암방정상식관조직중표체명현고우암조직( P<0.05).재식관암조직Smac여Caspase-3표체정정상관( P<0.05).결론：Smac재식관암조직중이상표체，유망성위식관암진단화기인치료적신파점.Smac기인여조망상관기인Caspase-3적이상표체가능재식관암암변중기협조작용.
Objective:To study the expression of Smac and its relationship with expression of Caspase-3 in esophageal carcinoma. Methods:Immunohistochemical S-P method was used to detect the expression of Smac and Caspase-3 proteins in 40 esophageal carcinoma tissues and 20 para-carcinoma tissues. Results:Smac protein was expressed in 23 of 40 esophageal carcinoma tissues (57.5%),but Smac protein showed high level in para–cancerous tissues(90.0%, P<0. 05).However, Smac protein expression was not associated with the different histological grade ( P>0. 05). Caspase-3 protein was expressed in 21 of 40 (52.5% ) esophageal carcinoma tissues, but Caspase-3 protein showed high level in para–cancerous tissues(85.0%, P<0. 05). Smac protein expression was positively related to Caspase-3 protein expression in esophageal carcinoma tissues ( P<0. 05). Conclusion:Aberrant expression of Smac may be a new target for diagnosis and gene treatment of esophageal carcinoma. The aberrant expression of Smac and apoptosis related gene Caspase-3 may play synergetic roles in process of carcinogenesis of esophageal carcinoma.
