CAJ | 학술논문

目的观察光动力疗法治疗脉络膜新生血管性疾病的临床疗效及安全性.方法回顾性分析2010年9月至2012年6月在贵阳医学院附属医院眼科门诊采用维替泊芬光动力疗法(PDT)治疗脉络膜新生血管性疾病50例65只眼的临床效果,比较PDT治疗前后的视力、CNV范围、光学相干断层成像(OCT)、荧光素血管造影(FFA)、吲哚青绿血管造影(ICGA)等图像资料.年龄相关性黄斑变性(AMD) 35例50只眼;中心性渗出性脉络膜视网膜病变(CEC)5例5只眼;息肉状脉络膜血管病变(PCV)4例4只眼;病理性近视(PM)5例5只眼;外伤性脉络膜裂伤CNV1例1只眼.结果全组50例65只眼PDT治疗后随访观察6个月,视力稳定和提高的AMD30只眼(60.00％)、CEC 4只眼(80.00％)、PCV 2只眼(50.00％)、PM 4只眼(80.00％)、脉络膜裂伤CNV 1只眼(100％);视力下降、CNV渗漏有进展的AMD 20只眼(40.00％)、CEC 1只眼(20.00％)、PCV 2只眼(50.00％)、PM 1只眼(20.00％).经ICGA、FFA检查发现CNV复发的30例30只眼,重复治疗2次的10例10只眼, 3次的3例3只眼.重复治疗时间:1个月者1例1只眼,3个月者8例8只眼,6个月者1例1只眼.所有病例均未见严重的不良反应.结论 PDT对治疗继发于不同病因的黄斑CNV安全、有效,可以减轻CNV的渗漏,延缓视力下降,但治疗后仍有复发需反复治疗.
목적 관찰광동력요법치료맥락막신생혈관성질병적림상료효급안전성.방법 회고성분석2010년9월지2012년6월재귀양의학원부속의원안과문진채용유체박분광동력요법(PDT)치료맥락막신생혈관성질병50례65지안적림상효과,비교PDT치료전후적시력、CNV범위、광학상간단층성상(OCT)、형광소혈관조영(FFA)、신타청록혈관조영(ICGA)등도상자료.년령상관성황반변성(AMD) 35례50지안;중심성삼출성맥락막시망막병변(CEC)5례5지안;식육상맥락막혈관병변(PCV)4례4지안;병이성근시(PM)5례5지안;외상성맥락막렬상CNV1례1지안.결과 전조50례65지안PDT치료후수방관찰6개월,시력은정화제고적AMD30지안(60.00％)、CEC 4지안(80.00％)、PCV 2지안(50.00％)、PM 4지안(80.00％)、맥락막렬상CNV 1지안(100％);시력하강、CNV삼루유진전적AMD 20지안(40.00％)、CEC 1지안(20.00％)、PCV 2지안(50.00％)、PM 1지안(20.00％).경ICGA、FFA검사발현CNV복발적30례30지안,중복치료2차적10례10지안, 3차적3례3지안.중복치료시간:1개월자1례1지안,3개월자8례8지안,6개월자1례1지안.소유병례균미견엄중적불량반응.결론 PDT대치료계발우불동병인적황반CNV안전、유효,가이감경CNV적삼루,연완시력하강,단치료후잉유복발수반복치료.
Objective To evaluate the clinical efficacy and safety of photodynamic therapy (PDT) for choroidal neovascularization (CNV).Methods A retrospective analysis from September 2010 to June 2012 using verteporfin photodynamic therapy (PDT) for treatment of choroidal neovascularization disease in 50 cases 65 eyes.Clinical effect,vision,CNV range,optical coherence tomography (OCT),Fluorescein angiography (FFA),indocyanine green angiography (ICGA) such as image PDT data before and after treatment were compared.Age-related macular degeneration (AMD) was 50 eyes in 35 cases; Central exudative chorioretinopathy (CEC) 5 eyes in 5 cases; Polypoidal choroidal vasculopathy (PCV) 4 eyes in 4 cases; pathologic myopia (PM) 5 eyes in 5 cases; Traumatic choroidal rupture CNV 1 eye in 1 case.Results Sixty-five eyes of 50 patients underwent PDT with 6 months follow-up.Visual Acuity (VA) kept stability and improved 30 eyes (69.76％) in AMD,4 eyes (80.00％) in CEC,2 eyes (50.00％) in PCV,4 eyes (80.00％) in PM,1 eye (100％) in choroid crack CNV.The CNV leakage was observed 20 eyes (46.51％) in AMD,1 eye (20.00％) in CEC,2 eyes (50.00％) in PCV,1 eye (20.00％) in PM.There were 30 recurrence eyes in 30 cases according to ICGA,and FFA examination,including 10 eyes in 10 cases with the second time retreatment and 3 eyes in 3 cases with third time retreatment.There was difference from the period of retreatment:1 eye in 1 case at the time of one month post treatment,5 eyes in 5 cases 3 months after treatment,and 1 eye in 1 case post treatment.All cases were no occurred severe complications.Conclusions PDT is a safe and effective treatment for patients of CNV caused by different macular disease,which can reduce CNV leakage,delay visual acuity decrease,however still needs re-treatment.