CAJ | 학술논문

地中海贫血(简称地贫)是最常见的血液系统遗传病之一,在我国主要分布于长江以南各省,其中两广、云贵及海南为高发省区.重型地贫不仅对患者的生活质量造成巨大的影响,而且为社会和家庭带来巨大的经济负担.输血、除铁和骨髓移植等是地贫的传统治疗方法,近年来由于干细胞技术的发展,地贫的基因治疗有了长足的进步.本文就地贫的基因治疗进行综述.
지중해빈혈(간칭지빈)시최상견적혈액계통유전병지일,재아국주요분포우장강이남각성,기중량엄、운귀급해남위고발성구.중형지빈불부대환자적생활질량조성거대적영향,이차위사회화가정대래거대적경제부담.수혈、제철화골수이식등시지빈적전통치료방법,근년래유우간세포기술적발전,지빈적기인치료유료장족적진보.본문취지빈적기인치료진행종술.
Thalassemia is one of the most common genetic blood diseases,mainly distributing in South China.Thalassemia major not only causes huge negative impact on the patient's quality of life,but also brings huge economic burden for society and family.Blood transfusion,iron chelation therapy and bone marrow transplantation are traditional treatment methods for thalassemia.In recent years,basing on the development of stem cell technology,gene therapy for thalassemia has developed very fast.Here we review the development of gene therapy for thalassemia.