CAJ | 학술논문

目的探讨内镜下醋酸联合靛胭脂染色法对早期胃癌及癌前病变的临床诊断价值.方法 2011年1-12月在我院就诊患者行常规胃镜检查,发现可疑病灶者300例,随机分为两组,染色组(150例)行内镜下醋酸联合靛胭脂染色后活检,对照组(150例)行内镜下靛胭脂染色后活检.结果染色组150例中共检出早期胃癌16例(10.7％)、重度不典型增生15例(10.0％)、中度不典型增生、肠上皮化生79例(52.7％),其余40例为胃炎.对照组150例中检出早期胃癌5例(3.3％)、重度不典型增生10例(6.7％)、中度不典型增生、肠上皮化生42例(28.0％),其余93例为胃炎.染色组早期胃癌及癌前病变检出率明显高于对照组,差异有统计学意义(P ＜0.001).醋酸联合靛胭脂染色后早期胃癌和重度不典型增生黏膜主要表现为黏膜退色,中度不典型增生和肠上皮化生黏膜主要表现为黏膜着色不良,慢性胃炎和正常黏膜主要表现为着色均匀.结论内镜下醋酸联合靛胭脂染色可显著提高早期胃癌和癌前病变的检出率,具有较高的临床应用价值.
목적 탐토내경하작산연합전연지염색법대조기위암급암전병변적림상진단개치.방법 2011년1-12월재아원취진환자행상규위경검사,발현가의병조자300례,수궤분위량조,염색조(150례)행내경하작산연합전연지염색후활검,대조조(150례)행내경하전연지염색후활검.결과 염색조150례중공검출조기위암16례(10.7％)、중도불전형증생15례(10.0％)、중도불전형증생、장상피화생79례(52.7％),기여40례위위염.대조조150례중검출조기위암5례(3.3％)、중도불전형증생10례(6.7％)、중도불전형증생、장상피화생42례(28.0％),기여93례위위염.염색조조기위암급암전병변검출솔명현고우대조조,차이유통계학의의(P ＜0.001).작산연합전연지염색후조기위암화중도불전형증생점막주요표현위점막퇴색,중도불전형증생화장상피화생점막주요표현위점막착색불량,만성위염화정상점막주요표현위착색균균.결론 내경하작산연합전연지염색가현저제고조기위암화암전병변적검출솔,구유교고적림상응용개치.
Objective To investigate the significance of chromoendoscopy with acetic acid and indigo carmine dye in the diagnosis of early gastric neoplasia and precancerous lesion.Methods After conventional electronic endoscopic diagnosis,From 2011 fanuay to 300 patients of suspicious lesions were randomly divided into endoscopic dye group and control group,each was 150 cases.Patients of endoscopic dye group were directly performed biopsy after acetic acid and indigo carmine dye,while in control group were performed biopsy after only indigo carmine dye.Results In the endoscopic dye group,16 early neoplasia (10.7％),15 severe atypical hyperplasia (10.0％),79 moderate atypical hyperplasia or Intestinal metaplasia (52.7％) and 40 chronic gastritis were found.In the control group,5 early neoplasia (3.3％),10 severe atypical hyperplasia (6.7％),42 moderate atypical hyperplasia or Intestinal metaplasia(28.0％) and 93 chronic gastritis were found.Early gastric cancer and precancerous lesion detection rate of endoscopic dye was significantly higher than that of the control group,and the difference was statistically significant (P ＜ 0.001).After samples were stained with acetic acid and indigo carmine dye,the image of the mucosa of early cancer and severe atypical hyperplasia were faded mucosa,and the image of moderate atypical hyperplasia and Intestinal metaplasia was dyed asymmetrical.Chronic gastritis and normal mucosa was showed dyed equality.Conclusion Chromoendoscopy with acetic acid and indigo carmine dye improve the detection rate of early gastric cancer and precancerous lesion,thereby of high application value.