CAJ | 학술논문

目的：比较不同剂量的阿伐他汀对于原发性高血压患者血浆硫化氢和一氧化氮水平的影响．方法选取2010年1月至2012年6月屯留县人民医院内科住院确诊原发性高血压病患者100例为研究对象，选取同期无明确高血压病、冠状动脉性心脏病（冠心病）、糖尿病病史的健康体检者30例为健康对照组．100例原发性高血压患者中随机选取组成阿伐他汀治疗40 mg组（38例）、阿伐他汀治疗20 mg组（42例），对照组（未用阿伐他汀，20例，治疗10 d．用定量ELISA法测定血浆硫化氢，硝酸还原法检测血清一氧化氮水平，比较不同剂量阿伐他汀对原发性高血压患者血浆硫化氢、一氧化氮水平的影响．结果原发性高血压患者血浆硫化氢、一氧化氮水平明显低于健康人群．阿伐他汀治疗10 d后，40 mg及20 mg治疗组患者的硫化氢及一氧化氮含量明显高于治疗前，40 mg剂量组和20 mg剂量组患者血浆硫化氢和一氧化氮水平治疗前后差值明显高于对照组，且40 mg剂量组差值明显高于20 mg剂量组．结论原发性高血压患者血浆硫化氢、一氧化氮水平较低，应用阿伐他汀治疗后可增加原发性高血压患者血浆硫化氢、一氧化氮水平．
목적：비교불동제량적아벌타정대우원발성고혈압환자혈장류화경화일양화담수평적영향．방법선취2010년1월지2012년6월둔류현인민의원내과주원학진원발성고혈압병환자100례위연구대상，선취동기무명학고혈압병、관상동맥성심장병（관심병）、당뇨병병사적건강체검자30례위건강대조조．100례원발성고혈압환자중수궤선취조성아벌타정치료40 mg조（38례）、아벌타정치료20 mg조（42례），대조조（미용아벌타정，20례，치료10 d．용정량ELISA법측정혈장류화경，초산환원법검측혈청일양화담수평，비교불동제량아벌타정대원발성고혈압환자혈장류화경、일양화담수평적영향．결과원발성고혈압환자혈장류화경、일양화담수평명현저우건강인군．아벌타정치료10 d후，40 mg급20 mg치료조환자적류화경급일양화담함량명현고우치료전，40 mg제량조화20 mg제량조환자혈장류화경화일양화담수평치료전후차치명현고우대조조，차40 mg제량조차치명현고우20 mg제량조．결론원발성고혈압환자혈장류화경、일양화담수평교저，응용아벌타정치료후가증가원발성고혈압환자혈장류화경、일양화담수평．
Objective To observe the effect of different doses of atorvastatin on the plasma hydrogen sulfide (H2S) and nitric oxide (NO) levels in patients with essential hypertensive. Methods One hundred patients with essential hypertension in the People’s Hospital of Tunliu County from 2010-2012 were selected as research subjects. Thirty healthy patients were chosen as the control. The patients with essential hypertension were randomly divided into atorvastatin 40 mg/d group (n=38), atorvastatin 20 mg/d group (n=42) and control group (without atorvastatin, n=20) . The plasma H2S level of was detected by ELISA and serum NO by nitrate reductase assay. Results The plasma H2S and NO levels were lower in patients with essential hypertension than those in healthy subjects. The levels of H2S and NO in patients given atorvastatin (40 mg/d and 20 mg/d) were higher after treatment than before treatment. The differences of plasma H2S and NO levels between before and after treatment in atorvastatin 40 mg/d group and atorvastatin 20 mg/d group were higher than those in control group, and the differences were also higher in atorvastatin 40 mg/d group than those in atorvastatin 20 mg/d group. Conclusion The plasma H2S and NO levels were lower in patients with essential hypertension. Atorvastatin could increase the plasma H2S and NO levels in patients with essential hypertension.