CAJ | 학술논문

目的：研究真菌植物提取物AMH-D的体内抗肿瘤作用，与环磷酰胺是否具有联合作用以及联合作用的形式和强度，为抗癌药物的开发提供科研基础．方法昆明种小鼠右腋皮下接种S-180肿瘤细胞，随机分组后，第2天开始腹腔注射给药，隔天给药1次，第11天处死小鼠，剥离并称重肿瘤，以肿瘤重量作为分析评价指标．结果提取物AMH-D能显著抑制S-180的生长，在剂量为150 mg/kg时抑瘤率达50.45%，其肿瘤抑制作用呈现剂量-效应关系．AMH-D对小鼠体重增长没有明显的影响．AMH-D与环磷酰胺具有体内协同抗肿瘤作用．结论真菌植物提取物AMH-D具有体内抑制S-180肿瘤作用，并与临床抗癌药物环磷酰胺具有体内联合抗癌作用．
목적：연구진균식물제취물AMH-D적체내항종류작용，여배린선알시부구유연합작용이급연합작용적형식화강도，위항암약물적개발제공과연기출．방법곤명충소서우액피하접충S-180종류세포，수궤분조후，제2천개시복강주사급약，격천급약1차，제11천처사소서，박리병칭중종류，이종류중량작위분석평개지표．결과제취물AMH-D능현저억제S-180적생장，재제량위150 mg/kg시억류솔체50.45%，기종류억제작용정현제량-효응관계．AMH-D대소서체중증장몰유명현적영향．AMH-D여배린선알구유체내협동항종류작용．결론진균식물제취물AMH-D구유체내억제S-180종류작용，병여림상항암약물배린선알구유체내연합항암작용．
Objective Study the anti-tumor effects in vivo of AMH-D on S-180 cell lines, the synergistic effects of AMH-D and cyclophosphamide,and investigate the way and its strength of the effect. Provide the basis for the development of anti-cancer drug. Methods Kunming mice were transplanted with S-180 tumor cells subcutaneously in the right armpit. Intraperitoneal injection was done after randomization on the next day. Mice were killed on the eleventh day, and tumors were stripped and weighed. The tumor weight was used as indicator for analysis and evaluation. Results The results showed that AMH-D could effectively inhibit the growth of S180 cells transplanted tumor. The tumor inhibition rate was 50.45%at the dose of 150 mg/kg, with a dose-effect relationship. There were no obvious impacts on the growth of the weight of mice. The results showed that AMH-D had a synergistic effect combined with cyclophosphamide within a certain dose. Conclusion Fungus extract AMH-D has a great effect on anti-tumor in vivo of S180 cells transplanted tumor, and has a synergistic effect combined with cyclophosphamide within a certain dose.