中华老年多器官疾病杂志
中華老年多器官疾病雜誌
중화노년다기관질병잡지
CHINESE JOURNAL OF MULTIPLE ORGAN DISEASES IN THE ELDERLY
2013年
10期
729-732
,共4页
周宏伟%古永建%王志红%刘默%曹志刚%彭朝津%杜瑜%杨清明
週宏偉%古永建%王誌紅%劉默%曹誌剛%彭朝津%杜瑜%楊清明
주굉위%고영건%왕지홍%류묵%조지강%팽조진%두유%양청명
地西他滨%老年人%白血病, 髓样, 急性%医院内感染%中性粒细胞减少
地西他濱%老年人%白血病, 髓樣, 急性%醫院內感染%中性粒細胞減少
지서타빈%노년인%백혈병, 수양, 급성%의원내감염%중성립세포감소
decitabine%aged%leukemia,myeloid,acute%nosocomial infection%neutropenia
目的:分析地西他滨单药或联合低剂量化疗治疗老年急性髓系白血病医院内感染的临床特点及易感因素。方法回顾性分析2009年9月至2012年10月接受地西他滨单药或联合低剂量化疗治疗的10例老年急性髓系白血病患者医院内感染发生率、感染部位、致病菌和易感因素等。结果10例老年患者治疗后医院内感染率为70%,例次感染率为46.7%,感染部位以呼吸系统最多见(占52.4%),致病菌以革兰阴性杆菌为主。化疗后骨髓抑制、粒细胞减少者感染率明显增高;与地西他滨联合低剂量化疗方案比较,地西他滨单药方案骨髓抑制、粒细胞减少发生率和医院内感染率降低。结论老年急性髓系白血病患者是医院内感染的易感人群,骨髓抑制、粒细胞减少是其易感因素。地西他滨单药方案治疗老年急性髓系白血病可降低医院内感染发生率。
目的:分析地西他濱單藥或聯閤低劑量化療治療老年急性髓繫白血病醫院內感染的臨床特點及易感因素。方法迴顧性分析2009年9月至2012年10月接受地西他濱單藥或聯閤低劑量化療治療的10例老年急性髓繫白血病患者醫院內感染髮生率、感染部位、緻病菌和易感因素等。結果10例老年患者治療後醫院內感染率為70%,例次感染率為46.7%,感染部位以呼吸繫統最多見(佔52.4%),緻病菌以革蘭陰性桿菌為主。化療後骨髓抑製、粒細胞減少者感染率明顯增高;與地西他濱聯閤低劑量化療方案比較,地西他濱單藥方案骨髓抑製、粒細胞減少髮生率和醫院內感染率降低。結論老年急性髓繫白血病患者是醫院內感染的易感人群,骨髓抑製、粒細胞減少是其易感因素。地西他濱單藥方案治療老年急性髓繫白血病可降低醫院內感染髮生率。
목적:분석지서타빈단약혹연합저제양화료치료노년급성수계백혈병의원내감염적림상특점급역감인소。방법회고성분석2009년9월지2012년10월접수지서타빈단약혹연합저제양화료치료적10례노년급성수계백혈병환자의원내감염발생솔、감염부위、치병균화역감인소등。결과10례노년환자치료후의원내감염솔위70%,례차감염솔위46.7%,감염부위이호흡계통최다견(점52.4%),치병균이혁란음성간균위주。화료후골수억제、립세포감소자감염솔명현증고;여지서타빈연합저제양화료방안비교,지서타빈단약방안골수억제、립세포감소발생솔화의원내감염솔강저。결론노년급성수계백혈병환자시의원내감염적역감인군,골수억제、립세포감소시기역감인소。지서타빈단약방안치료노년급성수계백혈병가강저의원내감염발생솔。
Objective To investigate the clinical characteristics and susceptible factors of nosocomial infection in the elderly patients with acute myeloid leukemia(AML) treated by decitabine alone or with low-dose chemotherapy. Methods A retrospective analysis was carried out on 10 elderly patients with AML who were treated by decitabine with or without low-dose chemotherapy in our department from September 2009 to October 2010. The incidence of nosocomial infection, most commonly infected sites, pathogenic bacteria and the susceptible factors were collected and analyzed in the cohort during the chemotherapeutic period. Results The incidence of nosocomial infection was 70%, and case infection rate was 46.7%in this study. The most commonly infected site was respiratory system, accounting for 52.4%, and the common pathogenic bacteria were mainly Gram-negative ones. There was a markedly increased infection rate in the patients with myelosuppression and neutropenia. The incidence of myelosuppression and neutropenia was lower in the regimen of single decitabine than that in the schedule of decitabine combined with low-dose chemotherapy. Conclusions The elderly patients with AML are susceptible to nosocomial infection. Myelosuppression and neutropenia are the susceptible factors for the infection. Exclusive decitabine regimen reduces the incidence of nosocomial infection in these elderly patients.