CAJ | 학술논문

目的：：探讨卡维地洛与比索洛尔治疗慢性心力衰竭(chronic heart failure,CHF)的临床疗效。方法：回顾性分析我院2010年1月~2012年12月收治的CHF患者124例的临床资料,随机将全部患者分为卡维地洛组和比索洛尔组,观察两组患者的各项指标及临床疗效。结果：治疗后LVEF、LVEDV、LVESV、FS较治疗前均明显改善(P<0.05)；卡维地洛组与比索洛尔组比较,治疗后,LVEF、LVEDV、LVESV有统计学差异(P<0.05)。治疗后两组患者的心率、收缩压、舒张压较治疗前均明显改善(P<0.05)；另外,治疗后,卡维地洛组收缩压、舒张压改善优于比索洛尔组,有统计学差异(P<0.05)。但是减慢心率以比索洛尔作用明显(P<0.05)。两组患者的总有效率比较,差异无显著性(P>0.05)。结论：卡维地洛和索洛尔治疗慢性心力衰竭患者,两者的治疗效果很相似,都可以起到很好的改善心力衰竭患者的心功能的作用,在改善左心室功能效果方面,卡维地洛要稍微好于比索洛尔。
목적：：탐토잡유지락여비색락이치료만성심력쇠갈(chronic heart failure,CHF)적림상료효。방법：회고성분석아원2010년1월~2012년12월수치적CHF환자124례적림상자료,수궤장전부환자분위잡유지락조화비색락이조,관찰량조환자적각항지표급림상료효。결과：치료후LVEF、LVEDV、LVESV、FS교치료전균명현개선(P<0.05)；잡유지락조여비색락이조비교,치료후,LVEF、LVEDV、LVESV유통계학차이(P<0.05)。치료후량조환자적심솔、수축압、서장압교치료전균명현개선(P<0.05)；령외,치료후,잡유지락조수축압、서장압개선우우비색락이조,유통계학차이(P<0.05)。단시감만심솔이비색락이작용명현(P<0.05)。량조환자적총유효솔비교,차이무현저성(P>0.05)。결론：잡유지락화색락이치료만성심력쇠갈환자,량자적치료효과흔상사,도가이기도흔호적개선심력쇠갈환자적심공능적작용,재개선좌심실공능효과방면,잡유지락요초미호우비색락이。
Objective:To investigate the clinical efficacy of carvedilol and bisoprolol in treatment of chronic heart failure. Methods:Analysis of the clinical data of 124 cases of CHF patients in our hospital from January 2010 to December 2012,all patients were divided into randomly carvedilol and bisoprolol group, the indexes were observed in two groups of patients and clinical effect.Results: after the treatment, LVEF, LVEDV, LVESV, FS compared with those before treatment were significantly improved (p<0.05);compared with carvedilol, bisoprolol group after treatment, there were significant differences in LVEF, LVEDV, LVESV (P<0.05). The two groups after treatment in patients with heart rate, systolic pressure, diastolic pressure than before treatment were significantly improved (p<0.05);in addition, after the treatment of carvedilol group, systolic pressure, diastolic pressure is better than bisoprolol group, there were significant differences (P<0.05).But the slow heart rate with bisoprolol obviously (p<0.05). The two groups of patients with total efficiency comparison,no significant difference (P>0.05).Conclusion:Bikaweidiluo and Snoyl therapy in patients with chronic heart failure, similar effect, can significantly improve heart function in patients with heart failure, carvedilol improve left ventricular function effect is slightly better than Snoyl, the clinical application can.