中国临床新医学
中國臨床新醫學
중국림상신의학
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
2013年
10期
945-948
,共4页
段捷华%樊小阳%覃睿%张惠%王钢%罗志华%翁田芳%张俊华%徐治超%何燕华%梁登贺%余冬林
段捷華%樊小暘%覃睿%張惠%王鋼%囉誌華%翁田芳%張俊華%徐治超%何燕華%樑登賀%餘鼕林
단첩화%번소양%담예%장혜%왕강%라지화%옹전방%장준화%서치초%하연화%량등하%여동림
氨溴索%支气管肺炎%氧化雾化吸入联合静脉滴注%氧化雾化吸入%静脉滴注
氨溴索%支氣管肺炎%氧化霧化吸入聯閤靜脈滴註%氧化霧化吸入%靜脈滴註
안추색%지기관폐염%양화무화흡입연합정맥적주%양화무화흡입%정맥적주
Ambroxol%Bronchial pneumonia%Oxidation-atomization inhalation combined with intrave-nous drop%Oxidation-atomization inhalation%Intravenous drop
目的：探讨氨溴索雾化及静滴联合用药与单独用药治疗小儿支气管肺炎的效果。方法选择2011-09～2013-03该院收治的101例支气管肺炎患儿，按入院时间半随机分为A、B、C三组。在综合治疗的基础上，A组采用氨溴索氧化雾化联合静脉滴注治疗，B组采用氨溴索氧化雾化治疗，C组采用氨溴索静脉滴注治疗，比较三组总有效率、胸片改变情况、住院天数和症状改善时间。结果（1）三组疗效比较差异均无统计学意义（P＞0.05）；（2）三组临床指标（症状、体征消失时间和住院天数）比较差异均无统计学意义（P＞0.05）；（3）三组治疗后胸片情况比较差异均无统计学意义（P＞0.05）；（4）三组对C反应蛋白（CRP）、白细胞计数（WBC）的影响比较差异均无统计学意义（P＞0.05）。两种给药途径联合应用治疗后hs-CRP恢复正常的例数明显多于单独应用者（ P＜0.05）。结论氨溴索氧化雾化联合静脉滴注治疗小儿支气管肺炎其疗效、临床指标、治疗后胸片、WBC与CRP的变化并不优于单用静脉滴注或氧驱动雾化吸入治疗，仅对hs-CRP的恢复存在优势，认为两种用药途经联合应用既浪费药源，增加病人负担，又浪费护士人力资源。
目的：探討氨溴索霧化及靜滴聯閤用藥與單獨用藥治療小兒支氣管肺炎的效果。方法選擇2011-09～2013-03該院收治的101例支氣管肺炎患兒，按入院時間半隨機分為A、B、C三組。在綜閤治療的基礎上，A組採用氨溴索氧化霧化聯閤靜脈滴註治療，B組採用氨溴索氧化霧化治療，C組採用氨溴索靜脈滴註治療，比較三組總有效率、胸片改變情況、住院天數和癥狀改善時間。結果（1）三組療效比較差異均無統計學意義（P＞0.05）；（2）三組臨床指標（癥狀、體徵消失時間和住院天數）比較差異均無統計學意義（P＞0.05）；（3）三組治療後胸片情況比較差異均無統計學意義（P＞0.05）；（4）三組對C反應蛋白（CRP）、白細胞計數（WBC）的影響比較差異均無統計學意義（P＞0.05）。兩種給藥途徑聯閤應用治療後hs-CRP恢複正常的例數明顯多于單獨應用者（ P＜0.05）。結論氨溴索氧化霧化聯閤靜脈滴註治療小兒支氣管肺炎其療效、臨床指標、治療後胸片、WBC與CRP的變化併不優于單用靜脈滴註或氧驅動霧化吸入治療，僅對hs-CRP的恢複存在優勢，認為兩種用藥途經聯閤應用既浪費藥源，增加病人負擔，又浪費護士人力資源。
목적：탐토안추색무화급정적연합용약여단독용약치료소인지기관폐염적효과。방법선택2011-09～2013-03해원수치적101례지기관폐염환인，안입원시간반수궤분위A、B、C삼조。재종합치료적기출상，A조채용안추색양화무화연합정맥적주치료，B조채용안추색양화무화치료，C조채용안추색정맥적주치료，비교삼조총유효솔、흉편개변정황、주원천수화증상개선시간。결과（1）삼조료효비교차이균무통계학의의（P＞0.05）；（2）삼조림상지표（증상、체정소실시간화주원천수）비교차이균무통계학의의（P＞0.05）；（3）삼조치료후흉편정황비교차이균무통계학의의（P＞0.05）；（4）삼조대C반응단백（CRP）、백세포계수（WBC）적영향비교차이균무통계학의의（P＞0.05）。량충급약도경연합응용치료후hs-CRP회복정상적례수명현다우단독응용자（ P＜0.05）。결론안추색양화무화연합정맥적주치료소인지기관폐염기료효、림상지표、치료후흉편、WBC여CRP적변화병불우우단용정맥적주혹양구동무화흡입치료，부대hs-CRP적회복존재우세，인위량충용약도경연합응용기낭비약원，증가병인부담，우낭비호사인력자원。
Objective To explore the therapeutic effect of combination use of oxidation-atomization inhala-tion and intravenous drop of ambroxol and their separate use in the treatment of children bronchial pneumonia .Meth-ods From September 2011 to March 2013 101 children with bronchial pneumonia , according to the admission time , were randomly divided into A , B, C groups.On the basis of comprehensive treatment , group A was treated with oxi-dation-atomization inhalation combined with intravenous drop of ambroxol , group B with oxidation-atomization inhala-tion of ambroxol , group C with intravenous drop of ambroxol .The comparison between 3 groups was performed of the total efficiency, the change of chest X-ray, days of hospitalization and symptom improvement time .Results (1) There was no statistically difference in total effective rate between 3 groups(P>0.05);(2)There was no statistically difference in clinical indexes(symptom improvement,day of hospitalization) between 3 groups(P>0.05);(3)After 7 days of treatment there was no statistically difference in change of chest X-ray between 3 groups(P>0.05);(4)No statistical significance among the 3 groups in changes WBC and CRP ( P>0.05 ) .But the number of cases of hs-CRP returned to normal in A group were more than B or C group ( P<0.05 ) .Conclusion The efficacy and the clinical index changes after treatment , WBC, chest X-ray and CRP of ambroxol oxidation-atomization inhalation combined with intravenous infusion of ambroxol in the treatment of children bronchial pneumonia is not superior to treatment with intravenous infusion or oxygen-driven inhalation of ambroxol , only there is advantage to restore hs-CRP, consider the combination of two routes of drug use should waste pharmaceutical sesource , increase the burden of patients , and waste of the nursing human resource .
