CAJ | 학술논문

目的：探讨阿托伐他汀和通心络对颈动脉粥样硬化斑块和血脂的影响。方法：选择67例颈动脉硬化斑块患者，随机分成3组，阿托伐他汀组、通心络组、联合治疗组（阿托伐他汀＋通心络），观察12周。观察治疗前后患者颈动脉内膜-中层厚度，斑块面积，斑块积分和血脂的变化。结果：3组治疗前后颈动脉IMT和斑块面积均缩小，斑块总积分减少，治疗后与治疗前相比差异有统计学意义，组间比较，联合治疗组颈动脉IMT和斑块面积和斑块总积分优于单药治疗组，差异有统计学意义（ P＜0.05，P＜0.01），阿托伐他汀组与通心络组比较，治疗后颈动脉IMT和斑块面积，差异有统计学意义（P＜0.05），斑块总积分差异无统计学意义（ P＞0.05）。联合治疗组TC、LDL-C、TG下降幅度均高于单独用药组，差异有统计学意义（ P＜0.05），通心络组治疗前后TG差异有统计学意义（ P＜0.05）。阿托伐他汀组与通心络组治疗后比较， TC、LDL -C、TG差异有统计学意义（ P＜0.05），通心络组降TG效果优于阿托伐他汀组（P＜0.05），差异有统计学意义。结论：阿托伐他汀和通心络联合治疗作用互补，对颈动脉内膜-中层厚度，斑块面积，斑块积分和血脂的影响大于单药治疗。
목적：탐토아탁벌타정화통심락대경동맥죽양경화반괴화혈지적영향。방법：선택67례경동맥경화반괴환자，수궤분성3조，아탁벌타정조、통심락조、연합치료조（아탁벌타정＋통심락），관찰12주。관찰치료전후환자경동맥내막-중층후도，반괴면적，반괴적분화혈지적변화。결과：3조치료전후경동맥IMT화반괴면적균축소，반괴총적분감소，치료후여치료전상비차이유통계학의의，조간비교，연합치료조경동맥IMT화반괴면적화반괴총적분우우단약치료조，차이유통계학의의（ P＜0.05，P＜0.01），아탁벌타정조여통심락조비교，치료후경동맥IMT화반괴면적，차이유통계학의의（P＜0.05），반괴총적분차이무통계학의의（ P＞0.05）。연합치료조TC、LDL-C、TG하강폭도균고우단독용약조，차이유통계학의의（ P＜0.05），통심락조치료전후TG차이유통계학의의（ P＜0.05）。아탁벌타정조여통심락조치료후비교， TC、LDL -C、TG차이유통계학의의（ P＜0.05），통심락조강TG효과우우아탁벌타정조（P＜0.05），차이유통계학의의。결론：아탁벌타정화통심락연합치료작용호보，대경동맥내막-중층후도，반괴면적，반괴적분화혈지적영향대우단약치료。
Objective:To explore the effect of Tongxinluo and Atorvastatin on carotid atherosclerotic plaque and blood lipid .Methods:Selected 67 patients with carotid atherosclerotic plaques , randomly divided into 3 groups, i.e.Atorvastatin group, Tongxinluo group and combination group (Atorvastatin +Tongxinluo), observed 12 weeks.Carotid artery intima-middle thickness, plaque area, plaque in-tegral and changes in blood lipids were observed .Results:Each treatment group ’ s carotid artery IMT and plaques area was decreased and total plaque score lowered after treatment (P <0.01).Comparison between groups regarding carotid IMT and plaque area and the total score:Atorvastatin +Tongxinluo group was better than the single drug groups with statistical difference .Atorvastatin group was significantly better (P<0.05) than Tongxinluo group except for plaques total score (P>0.05).Combination group TC TG, LDL -C declined greater than other groups (P<0.05).Tongxinluo group TG declined significantly after treatment (P<0.05).TAtorvastatin group showed better effect on TC TG , LDL -C difference (P<0.05), and Tongxinluo group was better to reduce TG (P<0.05). Conclusion:Atorvastatin in combination with Tongxinluo has better curative effect on carotid intima -middle thickness , plaque area , plaque score and blood lipids than monotherapy .