CAJ | 학술논문

目的：观察血液灌流联合血液透析（ HDP）治疗尿毒症皮肤瘙痒患者不同证候间的疗效差异。方法：将58例尿毒症顽固性皮肤瘙痒患者，按证候量表分为湿毒内停组、血虚生风组，采用血液灌流联合血液透析治疗，每月4～8次，共治疗8周。治疗前后测定各组瘙痒评分及血清全段甲状旁腺激素（ iPTH）和磷、镁等阳离子血清水平。结果：治疗后两组患者瘙痒症状均有明显缓解，尤以血虚生风组疗效显著，且与湿毒内停组疗效相比差异有统计学意义。结论：血液灌流联合血液透析能有效地改善患者皮肤瘙痒症状，且不同证候间疗效存在差异，这一结果为进一步寻找中医证候的生物学标记及临床治疗均提供了参考。
목적：관찰혈액관류연합혈액투석（ HDP）치료뇨독증피부소양환자불동증후간적료효차이。방법：장58례뇨독증완고성피부소양환자，안증후량표분위습독내정조、혈허생풍조，채용혈액관류연합혈액투석치료，매월4～8차，공치료8주。치료전후측정각조소양평분급혈청전단갑상방선격소（ iPTH）화린、미등양리자혈청수평。결과：치료후량조환자소양증상균유명현완해，우이혈허생풍조료효현저，차여습독내정조료효상비차이유통계학의의。결론：혈액관류연합혈액투석능유효지개선환자피부소양증상，차불동증후간료효존재차이，저일결과위진일보심조중의증후적생물학표기급림상치료균제공료삼고。
Objective:To observe the different curative effects of hemoperfusion combined with hemodialysis ( HDP) therapy treating patients with uremic cutaneous pruritus with different syndromes .Methods:According to the syndrome scale , fifty eight cases of uremia patients with intractable pruritus were divided into inside stasis of wet poison group , and blood deficiency generating wind group .Pa-tients were given hemoperfusion combined with hemodialysis therapy , four to eight times a month , for eight weeks .Pruritus score before and after treatment and cationic serum levels such as serum segment parathyroid hormone ( iPTH) and phosphorus , magnesium etc were measured in each group .Results:After treatment , prutitus were obviously relieved on patients in both groups , especially for blood defi-ciency generating wind group , and the curative effect was statistically different from that of the inside stasis of wet poison group .Conclu-sion:Hemoperfusion combined with hemodialysis can effectively improve patients ’ pruritus symptoms , and curative effect is different a-mong different syndromes .These results can provide reference for further biological markers of TCM syndromes and the clinical treat -ments.