CAJ | 학술논문

目的：研究α-细辛脑-（HP-β-CD）包合物的制备工艺。方法：以包合率为指标，比较超声波，饱和水溶液法，研磨法的包合效果，确定最优包合方法；采用正交实验，考察α-细辛脑与HP-β-CD比例、包合温度、包合时间对包合率的影响；以包合率和细辛脑的溶解度验证包合条件。结果：用超声波法包合率最高；最佳包合工艺条件为：α-细辛脑与HP-β-CD比例为1∶4，包合温度为35℃，包合时间为4 h；采用最佳条件验证，α-细辛脑的包合率为33.4%，α-细辛脑溶解度提高了14倍多。结论：该工艺简便，重复性好，能使α-细辛脑的溶解度得到提高，适用于α-细辛脑包合。
목적：연구α-세신뇌-（HP-β-CD）포합물적제비공예。방법：이포합솔위지표，비교초성파，포화수용액법，연마법적포합효과，학정최우포합방법；채용정교실험，고찰α-세신뇌여HP-β-CD비례、포합온도、포합시간대포합솔적영향；이포합솔화세신뇌적용해도험증포합조건。결과：용초성파법포합솔최고；최가포합공예조건위：α-세신뇌여HP-β-CD비례위1∶4，포합온도위35℃，포합시간위4 h；채용최가조건험증，α-세신뇌적포합솔위33.4%，α-세신뇌용해도제고료14배다。결론：해공예간편，중복성호，능사α-세신뇌적용해도득도제고，괄용우α-세신뇌포합。
Objective: To optimize the preparation process of α-asarone hydroxypropyl-β-cyclodextrin inclusion. Methods:Inclusion ratio as the indicator, the inclusion effect of ultrasonic method, saturated water solution method and grinding method was compared to determine the optimal inclusion method ; by orthogonal experiment, the influence of α-asarone and hydrox-ypropyl-β-cyclodextrin ratio, inclusion temperature and inclusion time on inclusion ratio was tested; the inclusion conditions was validated by inclusion rate and the solubility of α-asarone. Results: The best method was ultrasonic method; the best condition was that ratio of ofα-asarone and hydroxypropyl-β-cyclodextrin was1∶4, inclusion temperature was 35 ℃ and that the inclusion time was 4 hours; according to the best conditions for validation, α-asarone inclusion rate was 33.4%, and the solu-bility of asarone increased for more than 14 times. Conclusion: The ultrasonic method is simple and reproducible and can im-prove the solubility of α-asarone as well as be suitable for α-asarone inclusion.