CAJ | 학술논문

目的：观察参苓白术散加味治疗肺癌骨转移的疗效。方法：将128例本病患者随机分为治疗组和对照组各64例。治疗组采用参苓白术散加味治疗，对照组采用帕米膦酸二钠、塞来西布结合支持疗法治疗。观察比较两组患者镇痛效果、生存质量、生存期。结果：治疗组脱落5例，对照组脱落8例；综合疗效总有效率治疗组为66.1%，对照组为44.6%，治疗组优于对照组（P<0.05）；止痛效果总有效率治疗组为71.2%，对照组为42.9%，治疗组优于对照组，差异有统计学意义（P<0.05）；生活质量的改善对照组提高率为28.6%，治疗组提高率为59.3%，治疗组优于对照组，差异有统计学意义（P<0.05）；两组治疗前后体重变化、两组生存期比较，差异均无统计学意义（P＞0.05）；治疗组治疗后白细胞计数优于对照组（P＜0.05）；并能显著改善恶心呕吐、便秘（P＜0．01）。结论：参苓白术散加味能较好地缓解肺癌骨转移疼痛，提高生存质量，而且未见明显毒副作用。
목적：관찰삼령백술산가미치료폐암골전이적료효。방법：장128례본병환자수궤분위치료조화대조조각64례。치료조채용삼령백술산가미치료，대조조채용파미련산이납、새래서포결합지지요법치료。관찰비교량조환자진통효과、생존질량、생존기。결과：치료조탈락5례，대조조탈락8례；종합료효총유효솔치료조위66.1%，대조조위44.6%，치료조우우대조조（P<0.05）；지통효과총유효솔치료조위71.2%，대조조위42.9%，치료조우우대조조，차이유통계학의의（P<0.05）；생활질량적개선대조조제고솔위28.6%，치료조제고솔위59.3%，치료조우우대조조，차이유통계학의의（P<0.05）；량조치료전후체중변화、량조생존기비교，차이균무통계학의의（P＞0.05）；치료조치료후백세포계수우우대조조（P＜0.05）；병능현저개선악심구토、편비（P＜0．01）。결론：삼령백술산가미능교호지완해폐암골전이동통，제고생존질량，이차미견명현독부작용。
Objective: To observe the analgesic effect on pain by Shen-ling-bai-zhu powder in bone metastasis of lung cancer. Methods: 128 patients were randomly divided into treatment and control groups, 64 cases in each group. Patients were treated with Shen-ling-bai-zhu powder, and pamidronate disodium and celecoxib, combined with support therapy in control group. The analgesic effect, quality of life, survival rate was observed. Results: The displacement was 5 and 8 cases respec-tively in treatment and control group; The total comprehensive effective rate was 66.1% and 44.6% respectively in treatment and control group, the effect of treatment group was significantly better than the control group (P<0.05); The comprehensive ef-fective rate of analgesic was 71.2% and 42.9% respectively in treatment and control group, the effect of treatment group was significantly better than the control group (P<0.05); The improvement of quality of life rate was 59.3% and 28.6% respectively in treatment and control group, the increase rate in treatment group wass better than the control group (P<0.05); The weight changes and survival between two groups showed no significant difference; The leucocyte count in the treatment group was bet-ter than the control group (P<0.05); The symptoms of nausea and vomitting and constipation relieved in treatment group (P<0.05).Conclusion: Shen-ling-bai-zhu powder can relieve the pain of bone metastasis of lung cancer and improve the quality of life, and there is no obvious side effect.