CAJ | 학술논문

目的：基于文本挖掘数据，探讨类风湿关节炎的证-症-法-方药规律。方法：在中国生物医学文献数据库中收集涉及类风湿关节炎关键词的所有文献数据，通过降噪处理以及基于敏感关键词频数统计的数据分层算法，挖掘类风湿关节炎的证型、症状、治法、方剂及中药规律，并对这些规律进行一维频次的解释及二维网络图的展示。结果：文本挖掘的类风湿关节炎临床证型表现虚实夹杂，以痰瘀痹阻、寒热错杂、肝肾亏虚、肝肾阴虚、气血不足证常见，相关脏腑多涉及肝、肾、脾；症状挖掘结果中频数较高的肿胀疼痛、晨僵、强直、功能障碍、关节畸形与临床实际相吻合，侧面从数据上佐证了文本挖掘的可参考性；方药的选择体现了活血通络、活血化瘀、理气化痰、清热解毒、益气养血、滋补肝肾的治疗原则。结论：通过文本挖掘回溯文献，并结合人工阅读降噪，能够比较客观的总结类风湿关节炎的证-症-法-方药规律，为临床医师诊疗提供有益的探索与参考依据，同时也为中医临床数据客观化提供一种特定的解决途径与方法。
목적：기우문본알굴수거，탐토류풍습관절염적증-증-법-방약규률。방법：재중국생물의학문헌수거고중수집섭급류풍습관절염관건사적소유문헌수거，통과강조처리이급기우민감관건사빈수통계적수거분층산법，알굴류풍습관절염적증형、증상、치법、방제급중약규률，병대저사규률진행일유빈차적해석급이유망락도적전시。결과：문본알굴적류풍습관절염림상증형표현허실협잡，이담어비조、한열착잡、간신우허、간신음허、기혈불족증상견，상관장부다섭급간、신、비；증상알굴결과중빈수교고적종창동통、신강、강직、공능장애、관절기형여림상실제상문합，측면종수거상좌증료문본알굴적가삼고성；방약적선택체현료활혈통락、활혈화어、리기화담、청열해독、익기양혈、자보간신적치료원칙。결론：통과문본알굴회소문헌，병결합인공열독강조，능구비교객관적총결류풍습관절염적증-증-법-방약규률，위림상의사진료제공유익적탐색여삼고의거，동시야위중의림상수거객관화제공일충특정적해결도경여방법。
Objective:To investigate the rules of symptom,syndrome,strategy and formula in the treatment of rheumatoid arthritis based on date mining.Methods:Collected all the data relates to the keywords of rheumatoid arthritis in Chinese Biomedical Literature Database.By the noise reduction and data hierarchical algorithm based on sensitive keywords frequency statistics,the rules of symptom,syndrome,strategy,formula and medicine of rheumatoid arthritis were mined,explaining their one-dimensional frequency and display their two-dimensional network diagram.Results:Syndrome manifestations of rheumatoid arthritis by text mining were as follows:blockage of phlegm and blood stasis,simultaneous occurrence of cold and heat,deficiency of liver and kidney,yin deifciency of liver and kidney,and qi and blood deifciency,related viscera being liver,kidney and spleen. Symptoms as swelling and pain,morning stiff,rigid,dysfunction and joint abnormalities with higher frequency by mining were consistent with the clinical practice,worthy of being referenced.The choice of formula and medicine embodied the principles of treatment such as promoting blood circulation to remove meridian obstruction,promoting blood circulation and removing blood stasis,regulating qi and resolving phlegm,heat clearing and detoxicating,invigorating qi and nourishing blood,and nourishing liver and kidney.Conclusion:By retrospective text mining of literature and artificial reading noise reduction,the rules of symptom,syndrome,strategy and formula in the treatment of rheumatoid arthritis could be objectively summarized,providing reference for clinical diagnosis and treatment,and a speciifc way for the objectiifcation of TCM clinical data.