中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2013年
30期
18-19,20
,共3页
开胸手术%低分子肝素%高凝
開胸手術%低分子肝素%高凝
개흉수술%저분자간소%고응
Thoracotomy%Low molecular weight heparin%Hypercoagulable
目的:低分子肝素的不同剂量对普胸外科患者术后凝血功能变化的影响。方法:选取普胸外科临床有效病例122例,随机分为对照组和术后注射不同剂量低分子肝素(LMWH)的试验Ⅰ组、Ⅱ组、Ⅲ组。观察患者术前和术后活化的部分凝血活酶时间(APTT)、凝血酶原时间(PT)、D-二聚体(D-D)、血小板计数(PLT)及纤维蛋白原(Fib)等指标,比较组间、组内的差异。结果:术后各组PT、APTT延长,Fib、D-D升高,PLT第3天降低而术后第5天开始升高,与术前比较差异有统计学意义(P<0.05)。结论:固定剂量(4250 U)的LMWH对改善术后高凝状态具有重要意义。
目的:低分子肝素的不同劑量對普胸外科患者術後凝血功能變化的影響。方法:選取普胸外科臨床有效病例122例,隨機分為對照組和術後註射不同劑量低分子肝素(LMWH)的試驗Ⅰ組、Ⅱ組、Ⅲ組。觀察患者術前和術後活化的部分凝血活酶時間(APTT)、凝血酶原時間(PT)、D-二聚體(D-D)、血小闆計數(PLT)及纖維蛋白原(Fib)等指標,比較組間、組內的差異。結果:術後各組PT、APTT延長,Fib、D-D升高,PLT第3天降低而術後第5天開始升高,與術前比較差異有統計學意義(P<0.05)。結論:固定劑量(4250 U)的LMWH對改善術後高凝狀態具有重要意義。
목적:저분자간소적불동제량대보흉외과환자술후응혈공능변화적영향。방법:선취보흉외과림상유효병례122례,수궤분위대조조화술후주사불동제량저분자간소(LMWH)적시험Ⅰ조、Ⅱ조、Ⅲ조。관찰환자술전화술후활화적부분응혈활매시간(APTT)、응혈매원시간(PT)、D-이취체(D-D)、혈소판계수(PLT)급섬유단백원(Fib)등지표,비교조간、조내적차이。결과:술후각조PT、APTT연장,Fib、D-D승고,PLT제3천강저이술후제5천개시승고,여술전비교차이유통계학의의(P<0.05)。결론:고정제량(4250 U)적LMWH대개선술후고응상태구유중요의의。
Objective:To compare the influence of different doses of low molecular weight heparin on blood coagulation system of patients who had received thoracic surgery. Method:A total of 122 thoracic post-operative cases were randomly divided into experimental and control groups. The patients in the experimental group were subjected to subcutaneous injection of LMWH on the postoperative. Preoperative and postoperative changes in activated partial thromboplastin time(APTT),prothrombin time(PT),D-dimer(D-D),plate-let count(PLT)and fibrinogen(Fib)and compared in intra-and inter-groups. Result:PT and APTT in each group was prolonged,Fib and D-D increased,PLT reduced on the 3rd day but then increased on the 5th day,with the difference being significant pre-and post-operation(P<0.05). Conclusion:Fixed-dose(4250 U)of LMWH is able to improve postoperative hypercoagulable state.