安徽医药
安徽醫藥
안휘의약
ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL
2014年
6期
1038-1041,1042
,共5页
姚海江%莫雨平%宋洪涛%韩向博%李志刚
姚海江%莫雨平%宋洪濤%韓嚮博%李誌剛
요해강%막우평%송홍도%한향박%리지강
外源性褪黑素%慢性应激%行为学%5-羟色胺%促肾上腺皮质激素释放激素%促肾上腺皮质激素%皮质酮
外源性褪黑素%慢性應激%行為學%5-羥色胺%促腎上腺皮質激素釋放激素%促腎上腺皮質激素%皮質酮
외원성퇴흑소%만성응격%행위학%5-간색알%촉신상선피질격소석방격소%촉신상선피질격소%피질동
MT%chronic stress%behavior%5-HT%CRH%ACTH%CORT
目的:通过观察不同剂量的外源性褪黑素对慢性应激抑郁模型大鼠行为学及血清中5-HT、CRH、ACTH、CORT含量的影响,探讨外源性褪黑素对抑郁症的治疗作用。方法48只SD大鼠随机分为4组:空白对照组、模型对照组、褪黑素高剂量组、褪黑素低剂量组,每组12只。采用慢性轻度不可预见性应激和孤养方法复制慢性应激抑郁模型,灌胃给予治疗组不同剂量(5.0、10.0 mg·kg-1)的褪黑素加以干预,以体重、糖水试验、旷野试验观察实验前后大鼠行为学的改变。应用酶联免疫吸附法对大鼠血清中5-HT、CRH、ACTH、CORT的含量进行检测。结果从第7天开始,模型组、褪黑素低量组、褪黑素高剂量组的体重增长趋势开始降低,从第14天开始,模型对照组大鼠体重有下降趋势;从第14天开始褪黑素低剂量组、褪黑素高剂量组的糖水摄入量增长趋势降低,模型对照组的糖水摄入量呈下降趋势;第21天,与模型对照组相比,褪黑素低剂量和褪黑素高剂量组大鼠的水平和垂直运动次数都有显著性增多。与空白对照组相比,模型对照组血清5-HT的含量降低、血清CRH、ACTH、CORT含量升高,与模型对照组相比,褪黑素低剂量组和褪黑素高剂量组的血清5-HT含量均显著升高,血清CRH、CORT、ACTH含量均显著降低。结论外源性褪黑素对慢性应激抑郁模型大鼠抑郁行为有改善作用,也可以提高慢性应激抑郁模型大鼠血清中5-HT的含量,降低慢性应激抑郁模型大鼠血清中CRH、ACTH、CORT的含量,但它们之间的具体量效关系有待进一步研究。
目的:通過觀察不同劑量的外源性褪黑素對慢性應激抑鬱模型大鼠行為學及血清中5-HT、CRH、ACTH、CORT含量的影響,探討外源性褪黑素對抑鬱癥的治療作用。方法48隻SD大鼠隨機分為4組:空白對照組、模型對照組、褪黑素高劑量組、褪黑素低劑量組,每組12隻。採用慢性輕度不可預見性應激和孤養方法複製慢性應激抑鬱模型,灌胃給予治療組不同劑量(5.0、10.0 mg·kg-1)的褪黑素加以榦預,以體重、糖水試驗、曠野試驗觀察實驗前後大鼠行為學的改變。應用酶聯免疫吸附法對大鼠血清中5-HT、CRH、ACTH、CORT的含量進行檢測。結果從第7天開始,模型組、褪黑素低量組、褪黑素高劑量組的體重增長趨勢開始降低,從第14天開始,模型對照組大鼠體重有下降趨勢;從第14天開始褪黑素低劑量組、褪黑素高劑量組的糖水攝入量增長趨勢降低,模型對照組的糖水攝入量呈下降趨勢;第21天,與模型對照組相比,褪黑素低劑量和褪黑素高劑量組大鼠的水平和垂直運動次數都有顯著性增多。與空白對照組相比,模型對照組血清5-HT的含量降低、血清CRH、ACTH、CORT含量升高,與模型對照組相比,褪黑素低劑量組和褪黑素高劑量組的血清5-HT含量均顯著升高,血清CRH、CORT、ACTH含量均顯著降低。結論外源性褪黑素對慢性應激抑鬱模型大鼠抑鬱行為有改善作用,也可以提高慢性應激抑鬱模型大鼠血清中5-HT的含量,降低慢性應激抑鬱模型大鼠血清中CRH、ACTH、CORT的含量,但它們之間的具體量效關繫有待進一步研究。
목적:통과관찰불동제량적외원성퇴흑소대만성응격억욱모형대서행위학급혈청중5-HT、CRH、ACTH、CORT함량적영향,탐토외원성퇴흑소대억욱증적치료작용。방법48지SD대서수궤분위4조:공백대조조、모형대조조、퇴흑소고제량조、퇴흑소저제량조,매조12지。채용만성경도불가예견성응격화고양방법복제만성응격억욱모형,관위급여치료조불동제량(5.0、10.0 mg·kg-1)적퇴흑소가이간예,이체중、당수시험、광야시험관찰실험전후대서행위학적개변。응용매련면역흡부법대대서혈청중5-HT、CRH、ACTH、CORT적함량진행검측。결과종제7천개시,모형조、퇴흑소저량조、퇴흑소고제량조적체중증장추세개시강저,종제14천개시,모형대조조대서체중유하강추세;종제14천개시퇴흑소저제량조、퇴흑소고제량조적당수섭입량증장추세강저,모형대조조적당수섭입량정하강추세;제21천,여모형대조조상비,퇴흑소저제량화퇴흑소고제량조대서적수평화수직운동차수도유현저성증다。여공백대조조상비,모형대조조혈청5-HT적함량강저、혈청CRH、ACTH、CORT함량승고,여모형대조조상비,퇴흑소저제량조화퇴흑소고제량조적혈청5-HT함량균현저승고,혈청CRH、CORT、ACTH함량균현저강저。결론외원성퇴흑소대만성응격억욱모형대서억욱행위유개선작용,야가이제고만성응격억욱모형대서혈청중5-HT적함량,강저만성응격억욱모형대서혈청중CRH、ACTH、CORT적함량,단타문지간적구체량효관계유대진일보연구。
Objective To investigate the therapeutic action of melatonin(MT)on depression by observing the influence of different do-ses of MT on behavior and the content of related serum hormones in rats with chronic stress.Methods Forty-eight SD rats were ran-domly divided into four groups:control group,model group,high-dose MT group,low-dose MT group,twelve rats in each group.By using chronic unpredictable mild stress and separation to establish the depression models,intragastric administration of different doses of me-latonin(5.0,1 0.0 mg·kg-1 )to the treatment groups and adopting body weight,sucrose consumption test and open-field test to ob-serve the changes of rats’behavior before and after the experiment.ELISA method was used to detect the content of the serum 5-HT, CRH,ACTH,CORT.Results Body weight increased lower in model group,high-dose group and low-dose group from d7.Body weight of model group got low from 1 4d.The increase in sucrose consumption in high-dose group and low-dose group became slow from d1 4, and the sucrose consumption of model group declined from d1 4;the number of times of horizontal and vertical movement of low-dose group and high-dose group had significant difference in comparison with model group after chronic stress.Compared with control group, the content of 5-HT decreased significantly and the content of CRH,ACTH,CORT increased significantly in model group.Compared with model group,the content of 5-HT increased significantly and the content of CRH,CORT and ACTH decreased significantly in high-dose MT group and low-dose MT group.Conclusions MT can improve the depression behavior of chronic stress rats,and it can in-crease the serum 5-HT content of chronic stress rats,and decrease the serum CRH,ACTH,CORT content of rats with chronic stress.