CAJ | 학술논문

目的：探讨阿立哌唑和利培酮对首发精神分裂症患者记忆功能的影响。方法112例首发精神分裂症患者随机分成阿立哌唑组和利培酮组，每组56例。在治疗前和治疗12周末采用韦氏记忆量表-第三版的空间广度测验(WMS-Ⅲ SST)、霍普金斯词汇学习测验-修订版(HVLT-R)、简单视觉空间记忆测验-修订版(BVMT-R)分别对工作记忆、言语记忆和视觉记忆领域进行评定。结果在治疗前，两组的WMS-Ⅲ SST HVLT-R 和BVMT-R得分比较均无统计学意义（P＞0.05）。在治疗12周后，两组的HVLT-R 和BVMT-R得分较治疗前比较均有统计学意义（P＜0.05）而治疗后两组间比较无统计学意义（P＞0.05）；阿立哌唑组在治疗后的WMS-Ⅲ SST得分较治疗前显著增加（P＜0.05），且治疗后两组间比较有统计学意义（P＜0.05），而利培酮治疗前后WMS-Ⅲ SST得分比较无统计学意义（P＞0.05）。结论阿立哌唑和利培酮对首发精神分裂症患者记忆功具有改善作用，阿立哌唑对某些记忆功能改善优于利培酮。
목적：탐토아립고서화리배동대수발정신분렬증환자기억공능적영향。방법112례수발정신분렬증환자수궤분성아립고서조화리배동조，매조56례。재치료전화치료12주말채용위씨기억량표-제삼판적공간엄도측험(WMS-Ⅲ SST)、곽보금사사회학습측험-수정판(HVLT-R)、간단시각공간기억측험-수정판(BVMT-R)분별대공작기억、언어기억화시각기억영역진행평정。결과재치료전，량조적WMS-Ⅲ SST HVLT-R 화BVMT-R득분비교균무통계학의의（P＞0.05）。재치료12주후，량조적HVLT-R 화BVMT-R득분교치료전비교균유통계학의의（P＜0.05）이치료후량조간비교무통계학의의（P＞0.05）；아립고서조재치료후적WMS-Ⅲ SST득분교치료전현저증가（P＜0.05），차치료후량조간비교유통계학의의（P＜0.05），이리배동치료전후WMS-Ⅲ SST득분비교무통계학의의（P＞0.05）。결론아립고서화리배동대수발정신분렬증환자기억공구유개선작용，아립고서대모사기억공능개선우우리배동。
Objective To explore the efficacy of aripiprazole and risperidone on memory function in patients with schizophrenia. Methods 112 first-episode patients with schizophrenia were random-ized to aripiprazole group(n=56) and risperidone group(n=56). All subjects were assessed with the Wechsler Memory Scale-ⅢSpatial Span Task(WMS-Ⅲ SST), the Hopkins Verbal Learning Test-Re-vised (HVLT-R) and The Brief Visuospatial Memory Test-Revised (BVMT-R).Results Both groups showed no statistical significance in WMS-Ⅲ SST, HVLT-R and BVMT-R scores in the baseline (P>0.05).The performances after 12 weeks of treatment in the both groups was higher than those in the baseline in all tests(P<0.05) except for the WMS-III SST in the risperidone group(P<0.05). After treatment, there was no significant difference between the two groups (P>0.05).Aripiprazole group was increased significantly compared with before treatment after treatment WMS-Ⅲ SST score (P<0.05), and after treatment there was a statistical significance between the two groups (P<0.05).Conclusion Memory impairments in the patients with first-episode schizophrenia was im-proved by aripiprazole and risperidone, and effect of aripiprazole on certain memory functions was better than those of risperidone.