CAJ | 학술논문

目的：观察阿托伐他丁对2型糖尿病颈内动脉内-中膜增厚的影响，探讨阿托伐他丁在2型糖尿病治疗中的作用。方法从收治的2型糖尿病患者中选取颈动脉轻中度增厚的120例，随机分为阿托伐他汀治疗组和对照组，每组60例。对照组在控制饮食、健康锻炼的基础上予以降血糖治疗，治疗组在对照组的基础上给予口服阿托伐他汀治疗。结果经过严格治疗6个月后，治疗组患者颈内-中膜的厚度较治疗前显著降低，差异有统计学意义（P<0.05）。对照组患者颈内-中膜的厚度较治疗前无明显变化，差异无统计学意义（P>0.05）。结论阿托伐他丁对2型糖尿病颈内动脉内-中膜增厚的干预效果明显，能降低颈内动脉内-中膜厚度，稳定并逆转粥样斑块，具有良好的临床价值。
목적：관찰아탁벌타정대2형당뇨병경내동맥내-중막증후적영향，탐토아탁벌타정재2형당뇨병치료중적작용。방법종수치적2형당뇨병환자중선취경동맥경중도증후적120례，수궤분위아탁벌타정치료조화대조조，매조60례。대조조재공제음식、건강단련적기출상여이강혈당치료，치료조재대조조적기출상급여구복아탁벌타정치료。결과경과엄격치료6개월후，치료조환자경내-중막적후도교치료전현저강저，차이유통계학의의（P<0.05）。대조조환자경내-중막적후도교치료전무명현변화，차이무통계학의의（P>0.05）。결론아탁벌타정대2형당뇨병경내동맥내-중막증후적간예효과명현，능강저경내동맥내-중막후도，은정병역전죽양반괴，구유량호적림상개치。
Objective To evaluate the influence the effect of atorvastatin for carotid artery intima-media thickness of type 2 diabetes. Methods 120 patients from march 2011 to November 2012 who were di-agnosed with type 2 diabetes as well as carotid artery intima-media thickness were selected,and ran-domly divided into atorvastatin treatment group(60 patients) and control group(60 patients). All the pa-tients were on diet and took exercise as hypoglycemic therapy. The patients in atorvastatin treatment group use atorvastatin. Results Compared with before treatment, intima-media thickness in atorvastatin treatment group was improved significantly (P<0.05), the difference was statistically significant. While intima-media thickness in control group was similar (P>0.05) with before treatment, the difference was not statistically significant.Conclusion The efficacy of atorvastatin on carotid intima-media thickness in patients with type 2 diabetes is significantly, it is much more valuable for patients with type 2 dia-betes.