CAJ | 학술논문

线粒体融合蛋白2（ Mfn2）是一种高度保守的跨膜GTP酶，由新鉴定的抑癌基因Mfn2编码，它的抗肿瘤作用跟丝裂原活化蛋白激酶（ MAPK）信号通路有关。 MAPK是Ras信号通路下游的一个主要支路，在细胞恶变和肿瘤浸润、转移过程中起着重要作用。本文对Mfn2的分子结构、调控机制及其在乳腺癌中与Ras-MAPK信号通路关系的最新研究进展作一综述。
선립체융합단백2（ Mfn2）시일충고도보수적과막GTP매，유신감정적억암기인Mfn2편마，타적항종류작용근사렬원활화단백격매（ MAPK）신호통로유관。 MAPK시Ras신호통로하유적일개주요지로，재세포악변화종류침윤、전이과정중기착중요작용。본문대Mfn2적분자결구、조공궤제급기재유선암중여Ras-MAPK신호통로관계적최신연구진전작일종술。
Mitochondrial fusion protein 2( Mfn2) is a highly conserved transmembrane GTP enzyme, which is encoded by a newly identified tumor suppressor gene Mfn2. The anti-tumor effect of Mfn2 is associated with the mitogen-activated protein kinase ( MAPK) signaling pathway. MAPK is a major downstream tributary of Ras signaling pathway, which plays an important role in the ma-lignant cells, leading to the tumor invasion and metastasis. In this review, we focus on the recent discoveries on the mechanisms in-volved in the regulation of Mfn2 and the relationship between Mfn2 and Ras-MAPK signaling pathway in breast cancer.