CAJ | 학술논문

目的：探讨尿毒清颗粒对慢性肾衰竭患者24h尿蛋白定量、肾功能、血脂及微炎症状态的疗效。方法169例确诊为慢性肾衰竭的患者随机分为对照组、药用炭片组、尿毒清颗粒组。对照组给予常规治疗，药用炭片组及尿毒清组在常规治疗基础上加用药用炭片或尿毒清颗粒，疗程8周。结果尿毒清颗粒显著改善慢性肾衰竭患者尿蛋白、肾功能、血脂及微炎症状态，与对照组、药用炭片组比较，差异有统计学意义(P<0.05)。药用炭片显著改善患者肾功能，对尿蛋白、血脂、微炎症状态无治疗作用。结论尿毒清颗粒通过减少蛋白尿、改善脂类紊乱、抑制微炎症状态，发挥改善患者肾功能及减少心血管事件、贫血、营养不良等并发症的作用。
목적：탐토뇨독청과립대만성신쇠갈환자24h뇨단백정량、신공능、혈지급미염증상태적료효。방법169례학진위만성신쇠갈적환자수궤분위대조조、약용탄편조、뇨독청과립조。대조조급여상규치료，약용탄편조급뇨독청조재상규치료기출상가용약용탄편혹뇨독청과립，료정8주。결과뇨독청과립현저개선만성신쇠갈환자뇨단백、신공능、혈지급미염증상태，여대조조、약용탄편조비교，차이유통계학의의(P<0.05)。약용탄편현저개선환자신공능，대뇨단백、혈지、미염증상태무치료작용。결론뇨독청과립통과감소단백뇨、개선지류문란、억제미염증상태，발휘개선환자신공능급감소심혈관사건、빈혈、영양불량등병발증적작용。
Objective To investigate the efficiency of Uremic Clearance Granules on Chronic Renal Failure for 24h urinary protein excretion, renal function, blood fat and micro-inflammation state. Methods 169 patients with Chronic Renal Failure were randomly divided into control group, Medicinal Charcoal Tablets group and Uremic Clearance Granules group. Control group were given routine therapy alone, Medicinal Charcoal Tablets group were given routine therapy and Medicinal Charcoal Tablets, Uremic Clearance Granules group were given routine therapy and Uremic Clearance Granules, treatments were maintained for 8 weeks. Results Compared with control group and Medicinal Charcoal Tablets group, levels of 24h urinary protein excretion, renal function、blood fat and micro-inflammation state obviously decreased in Uremic Clearance Granules group after therapy(P<0.05). Compared with control group, levels of renal function obviously decreased, levels of 24h urinary protein excretion, blood fat and micro-inflammation state did not changed in Medicinal Charcoal Tablets group after therapy. Conclusion By means of decreasing levels of 24h urinary protein excretion、blood fat and micro-inflammation state, Uremic Clearance Granules can improve renal function and decrease probability of cardiovascular event、anaemia and malnourish.