CAJ | 학술논문

目的：观察降钙素对腰椎椎间植骨融合术后的临床疗效。方法采用完全随机对照的前瞻性研究方法，将58例腰椎退变性滑脱患者随机分为2组，实验组行内固定植骨融合术并给予鲑鱼降钙素鼻喷剂和钙尔奇D治疗，对照组行内固定植骨融合术及钙尔奇D治疗。观察患者术后第2，4，6，8周时疼痛视觉模拟评分（ VAS）、Oswestry功能障碍指数（ ODI）和术后3个月时植骨融合情况。结果鲑鱼降钙素组术后VAS和ODI明显优于对照组（P＜0．05），术后3个月实验组植骨融合率（93．1％）高于对照组（78．5％）（P＜0．05）。结论鲑鱼降钙素可以减轻腰椎椎体植骨融合术后疼痛和改善术后功能障碍，且有助于椎体间植骨融合。
목적：관찰강개소대요추추간식골융합술후적림상료효。방법채용완전수궤대조적전첨성연구방법，장58례요추퇴변성활탈환자수궤분위2조，실험조행내고정식골융합술병급여해어강개소비분제화개이기D치료，대조조행내고정식골융합술급개이기D치료。관찰환자술후제2，4，6，8주시동통시각모의평분（ VAS）、Oswestry공능장애지수（ ODI）화술후3개월시식골융합정황。결과해어강개소조술후VAS화ODI명현우우대조조（P＜0．05），술후3개월실험조식골융합솔（93．1％）고우대조조（78．5％）（P＜0．05）。결론해어강개소가이감경요추추체식골융합술후동통화개선술후공능장애，차유조우추체간식골융합。
Objective To observe clinical efficacy of calcitonin on lumbar interbody fusion after surgery . Methods Using a fully randomized controlled research method ,58 cases of lumbar degenerative spondylolisthesis were randomly divided into two groups:experimental group were given salmon calcitonin nasal sprays and Caltrate D ,and the control group were given Caltrate D.The visual analogue scale(VAS) scores and Oswestry Disability Index (ODI) were evaluated in 2,4,6,8 weeks after surgery.The bone fusion was assessed after 3 months.Results The experimental group is significantly better in VAS scores and ODI than the control group ( P<0 .05 ) .The fusion rate in the experimental group and the control group were 93.1%and 78.5%respectively at 3 months(P<0.05).Conclusion Salmon calcito-nin can reduce postoperative pain ,improve postoperative dysfunction and interbody fusion .