CAJ | 학술논문

[目的]比较阿托伐他汀与非诺贝特治疗高脂血症伴胰岛素抵抗的疗效。[方法]78例高脂血症伴胰岛素抵抗患者随机分成两组，分别给予阿托伐他汀和非诺贝特，疗程为12周。比较两组治疗前后血清总胆固醇（TC）、甘油三脂（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FBG）、空腹胰岛素（FINS）、肝功能、肾功能、肌酸激酶（CK）及胰岛素抵抗指数（HOMA-IR）的变化。[结果]两组治疗后均能降低TG、LDL-C并能升高 HDL-C（ P ＜0．01），非诺贝特降低TG水平较阿托伐他汀更显著（ P ＜0．05），阿托伐他汀较非诺贝特降低TC、LDL-C及升高 HDL-C更显著（ P ＜0．05），并能降低FINS及HOMA-IR（ P＜0．05）。二者在FBG、肝功能、肾功能、CK的比较无统计学意义（ P ＞0．05）。[结论]阿托伐他汀比非诺贝特具有更好的调脂作用，并能改善胰岛素抵抗。
[목적]비교아탁벌타정여비낙패특치료고지혈증반이도소저항적료효。[방법]78례고지혈증반이도소저항환자수궤분성량조，분별급여아탁벌타정화비낙패특，료정위12주。비교량조치료전후혈청총담고순（TC）、감유삼지（TG）、고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）、공복혈당（FBG）、공복이도소（FINS）、간공능、신공능、기산격매（CK）급이도소저항지수（HOMA-IR）적변화。[결과]량조치료후균능강저TG、LDL-C병능승고 HDL-C（ P ＜0．01），비낙패특강저TG수평교아탁벌타정경현저（ P ＜0．05），아탁벌타정교비낙패특강저TC、LDL-C급승고 HDL-C경현저（ P ＜0．05），병능강저FINS급HOMA-IR（ P＜0．05）。이자재FBG、간공능、신공능、CK적비교무통계학의의（ P ＞0．05）。[결론]아탁벌타정비비낙패특구유경호적조지작용，병능개선이도소저항。
[Objective]To compare the efficacy of atorvastatin vs fenofibrate for the treatment of hyperlipi-demia with insulin resistance .[Methods] Totally 78 patients with hyperlipidemia and insulin resistance were randomly divided into two groups which were given atorvastatin and fenofibrate for 12 weeks ,respectively . Total cholesterol(TC) ,triglyceride(TG) ,high density lipoprotein cholesterol(HDL-C) ,low density lipopro-tein cholesterol(LDL-C) ,fasting blood glucose(FBG) ,fasting insulin(FINS) ,liver function ,kidney function , creatine kinase(CK) and homeostasis modal assessment insulin resistance(HOMA-IR) were compared before and after treatment .[Results]After treatment ,TG and LDL-C of two groups decreased and HDL-C increased ( P <0 .01) .Fenofibrate reduced TG level more significantly than atorvastatin ( P <0 .05) .Atorvastatin re-duced the levels of TC and LDL-C and increased HDL-C more significantly than fenofibrate ( P <0 .05) ,and reduced FINS and HOMA-IR( P <0 .05) .There was no significant difference in FBG ,liver function ,kidney function and CK between two groups ( P < 0 .05) .[Conclusion] Atorvastatin has a better lipid-regulating effect than fenofibrate ,and can improve insulin resistance .