CAJ | 학술논문

[目的]探讨2型糖尿病（T2DM）不同动脉血管病变中血小板计数（PLT）、血小板平均体积（MPV）及血小板分布宽度（PDW）的变化。[方法]180例T2DM患者根据踝臂指数（ABI）和颈动脉内膜中层厚度（IM T ）分组，单纯ABI ≤0．9组（A组）45例，单纯IM T＞0．8 mm组（B组）46例，ABI ≤0．9且IM T＞0．8 mm组（C组）39例，正常组（ABI＞0．9且IMT≤0．8 mm）50例，比较四组的体质量指数（BMI）、糖化血红蛋白（HbA1C）、血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、PLT、MPV、PDW。[结果]A组、B组和C组的MPV分别为（11．96±0．57）fl；（11．22±1．42）fl；（12．26±0．86）fl ，与正常组 MPV （9．67±1．56）fl比较，差异有显著性（F＝24．69，P ＜0．05），C组M PV与A组和B组比较差异无显著性（F值分别为0．09和0．12，P＞0．05）；与正常组比较，各组的PDW和PLT的差异无显著性（F值分别为0．20和0．25，P＞0．05）。[结论]T2DM各种动脉血管病变均与MPV相关，与PDW和PLT数量无关。
[목적]탐토2형당뇨병（T2DM）불동동맥혈관병변중혈소판계수（PLT）、혈소판평균체적（MPV）급혈소판분포관도（PDW）적변화。[방법]180례T2DM환자근거과비지수（ABI）화경동맥내막중층후도（IM T ）분조，단순ABI ≤0．9조（A조）45례，단순IM T＞0．8 mm조（B조）46례，ABI ≤0．9차IM T＞0．8 mm조（C조）39례，정상조（ABI＞0．9차IMT≤0．8 mm）50례，비교사조적체질량지수（BMI）、당화혈홍단백（HbA1C）、혈청총담고순（TC）、감유삼지（TG）、저밀도지단백담고순（LDL-C）、고밀도지단백담고순（HDL-C）、PLT、MPV、PDW。[결과]A조、B조화C조적MPV분별위（11．96±0．57）fl；（11．22±1．42）fl；（12．26±0．86）fl ，여정상조 MPV （9．67±1．56）fl비교，차이유현저성（F＝24．69，P ＜0．05），C조M PV여A조화B조비교차이무현저성（F치분별위0．09화0．12，P＞0．05）；여정상조비교，각조적PDW화PLT적차이무현저성（F치분별위0．20화0．25，P＞0．05）。[결론]T2DM각충동맥혈관병변균여MPV상관，여PDW화PLT수량무관。
[Objective] To explore the changes of platelet count(Pt) ,mean platelet volume(MPV) and platelet distribution width(PDW) in different artery diseases of type 2 diabetes mellitus(T2DM ) .[Methods]According to ankle brachial index(ABI) and carotid artery intima-media thickness(IMT) ,180 T2DM patients were divided into group A(simple ABI≤0 .9 ,n=45) ,group B(simple IMT>0 .8mm ,n=46) ,group C(ABI≤0 .9 and IMT>0 .8 mm ,n=39) and normal control group(ABI>0 .9 and IMT≤0 .8mm ,n=50) .Body mass index(BMI) ,glycated hemoglobin(HbA1c) ,total cholesterol(TC) ,triglyceride(TG) ,low density lipoprotein cholesterol(LDL-C) ,high density lipoprotein cholesterol(HDL-C) ,Pt count ,MPV and PDW were compared among 4 groups .[Results]MPV in group A ,B and C was (11 .96 ± 0 .57) ,(11 .22 ± 1 .42) and (12 .26 ± 0 .86) respectively ,and there was significant difference between group A ,B ,C and normal group(9 .67 ± 1 .56)( F=24 .69 ,P <0 .05) .There was no significant difference in MPV between group C and group A and B(F=0 .09 and 0 .12 ,P >0 .05) .There was also no significant difference in PDW and Pt count among 4 groups(F=0 .20 and 0 .25 ,P >0 .05) .[Conclusion]Various artery diseases of T 2DM are related to M PV ,but not related to PDW and Pt count .