CAJ | 학술논문

目的：研究右美托咪啶(dexmedetomidine,DEX)对血管平滑肌旳舒张作用,并探讨其作用机制。方法应用大鼠离体血管平滑肌张力记录法,观测DEX对大鼠离体肠系膜动脉环的作用及工具药对其作用的影响。结果 DEX对苯肾上腺素(PE,10-5 mol/L)预收缩的血管具有浓度依赖性的舒张作用,明显抑制由 PE和 KCl 诱导的血管收缩,增加硝普钠诱导的血管舒张。在PE(10-5 mol/L)预收缩基础上,加入乙酰胆碱(ACh)不能抑制 DEX 的舒张血管效应。扩张血管作用与内皮无关。在无钙的生理盐水溶液中,DEX对CaCl2收缩血管有明显抑制作用。结论 DEX有舒张血管的作用,其作用不依赖于内皮细胞。
목적：연구우미탁미정(dexmedetomidine,DEX)대혈관평활기적서장작용,병탐토기작용궤제。방법응용대서리체혈관평활기장력기록법,관측DEX대대서리체장계막동맥배적작용급공구약대기작용적영향。결과 DEX대분신상선소(PE,10-5 mol/L)예수축적혈관구유농도의뢰성적서장작용,명현억제유 PE화 KCl 유도적혈관수축,증가초보납유도적혈관서장。재PE(10-5 mol/L)예수축기출상,가입을선담감(ACh)불능억제 DEX 적서장혈관효응。확장혈관작용여내피무관。재무개적생리염수용액중,DEX대CaCl2수축혈관유명현억제작용。결론 DEX유서장혈관적작용,기작용불의뢰우내피세포。
Objective To investigate the dilating effect of dexmedetomidine (DEX)on isolated vascular smooth muscles and to explore the mechanism.Methods Tension of isolated mesenteric arterial rings of male Sprague-Dawley rats was recorded.The effects of DEX on the rings and the effects of DEX on vascular reaction induced by various drugs were recorded. Results DEX completely relaxed the contraction induced by phenylephrine (PE)and KCl in a concentration-dependent manner in endothelium intact mesenteric arterial rings in rats.The vasodilating effect of DEX was increased by sodium nitroprusside.In phenylephrine (10-5 mol/L)based on pre-vasoconstriction,adding acetylcholine could not suppress DEX’s vasodilating effect.Vasodilation was not related to the endothelial cells.In physiological saline solution without calcium,DEX significantly inhibited the contraction induced by addition of CaCl2 .Conclusion DEX can induce vasodilation in a concentration-dependent manner,which is not dependent on the endothelial cells.