CAJ | 학술논문

[目的]探讨人乳头瘤状病毒（ human papillomavirus ，HPV）在本院妇科门诊患者中的感染状况和亚型分布。[方法]应用基因芯片技术对2008年12月至2011年12月在本院门诊就诊的患者4775例进行 H PV 的21种亚型进行基因亚型检测。[结果]4775例患者中共检出HPV感染1415例（29．63％），其中单一型别感染1077例（22．55％），双重感染247例（5．17％），三重及三重以上感染例91例（1．91％）；高危型感染1309例（27．41％），低危险型别感染106例（2．22％）；HPV型别感染中以 HPV52感染率最高335例（7．02％）。不同年龄人群的H PV感染情况分析显示21～30岁组及51～60岁组 H PV感染率出现两次高峰，各年龄组中，均以高危型感染为主，组间比较有统计学意义（ P＜0．05）。高危型HPV持续感染是引起宫颈病变的必要条件，单一高危型、高危混合型与高低混合型三组致细胞学异常方面比较，在非典型鳞状细胞（不明确意义）（ASCUS ）、低度鳞状上皮内病变（LSIL）、高度鳞状上皮内病变（HSIL）、鳞状细胞癌抗原（SCC）中均有统计学意义（ P ＜0．05），高危混合型致细胞学异常者最高。[结论]本院门诊就诊患者中，HPV 感染以单一型别及高危型感染为主，尤以HPV52感染率最高，高危型 HPV感染尤甚多重高危型 HPV感染更易引起宫颈病变。
[목적]탐토인유두류상병독（ human papillomavirus ，HPV）재본원부과문진환자중적감염상황화아형분포。[방법]응용기인심편기술대2008년12월지2011년12월재본원문진취진적환자4775례진행 H PV 적21충아형진행기인아형검측。[결과]4775례환자중공검출HPV감염1415례（29．63％），기중단일형별감염1077례（22．55％），쌍중감염247례（5．17％），삼중급삼중이상감염례91례（1．91％）；고위형감염1309례（27．41％），저위험형별감염106례（2．22％）；HPV형별감염중이 HPV52감염솔최고335례（7．02％）。불동년령인군적H PV감염정황분석현시21～30세조급51～60세조 H PV감염솔출현량차고봉，각년령조중，균이고위형감염위주，조간비교유통계학의의（ P＜0．05）。고위형HPV지속감염시인기궁경병변적필요조건，단일고위형、고위혼합형여고저혼합형삼조치세포학이상방면비교，재비전형린상세포（불명학의의）（ASCUS ）、저도린상상피내병변（LSIL）、고도린상상피내병변（HSIL）、린상세포암항원（SCC）중균유통계학의의（ P ＜0．05），고위혼합형치세포학이상자최고。[결론]본원문진취진환자중，HPV 감염이단일형별급고위형감염위주，우이HPV52감염솔최고，고위형 HPV감염우심다중고위형 HPV감염경역인기궁경병변。
[Objective]To explore the situation of infection and gene subtype distribution of human papillom avirus (HPV) among patients visiting to clinic service of gynecological department in our hospital .[Methods]Gene chip was used to detect 21 gene subtypes of HPV in 4775 patients visiting to clinic service in our hospital from Dec .2008 to Dec .2011 .[Results] Among 4775 patients ,1415 patients(29 .63% ) were diagnosed as HPV infection including single subtype infec-tion in 1077 patients(22 .55% ) ,double subtype infection in 247 patients(5 .17% ) and complex subtype infection in 91 pa-tients(1 .91% ) . There were high-risk infection in 1309 patients (27 .41% ) and low-risk infection in 106 patients (2 .22% ) .Of all the subtypes of HPV ,the infection rate of HPV52 was the highest (7 .02% ,335 cases) .The analysis of HPV infection in patients with different age showed that the infection rate of HPV in 21~20 age group and 51~60 age group were high ,and the main was high risk infection .There was significant difference among different age groups ( P<0 .05) .High-risk HPV constant infection was necessary to cervical lesion .There were significant differences in abnormal cytology caused by single high-risk HPV infection ,high-risk HPV co-infection and high-risk and low-risk co-infection a-mong atypical squamous cell of undetermined significacne (ASCUS) ,low squamous intraepithelial lesion (LSIL) ,high squamous intraepithelial lesion(HSIL) and squamous cell carcinoma(SCC)( P <0 .05) .Abnormal cytology caused by high-risk HPV co-infection was the highest .[Conclusion]In patients visiting to clinic service of our hospital ,HPV infec-tion is mainly single subtype and high-risk infection .Especially the infection rate of HPV52 is the highest .High-risk HPV infection is more apt to cause cervical lesion than complex high-risk HPV infection .