CAJ | 학술논문

目的探讨XAGE-1b和CD133在良、恶性前列腺组织的表达及意义.方法 50例前列腺癌为病例组,以30例良性前列腺增生患者为对照组,应用免疫组织化学技术检测二组XAGE-1b的表达,并分析其不同临床病理特征中表达的差异.结果 XAGE-1b和CD133在病例组阳性率均明显高于对照组的阳性率,差异均有显著的统计学意义(p ＜0.01)XAGE-1b和CD133的表达与前列腺癌临床分期,远处转移等指标具有明显的关系(P＜0.05).结论 XAGE-1b和CD133在前列腺癌中高表达,可优先选择该基因作为前列腺癌免疫治疗靶点.
목적 탐토XAGE-1b화CD133재량、악성전렬선조직적표체급의의.방법 50례전렬선암위병례조,이30례량성전렬선증생환자위대조조,응용면역조직화학기술검측이조XAGE-1b적표체,병분석기불동림상병리특정중표체적차이.결과 XAGE-1b화CD133재병례조양성솔균명현고우대조조적양성솔,차이균유현저적통계학의의(p ＜0.01)XAGE-1b화CD133적표체여전렬선암림상분기,원처전이등지표구유명현적관계(P＜0.05).결론 XAGE-1b화CD133재전렬선암중고표체,가우선선택해기인작위전렬선암면역치료파점.
Objectives To explore the expression and significance of XAGE-1b and CD133 in cancer of prostate.Methods 50 cases with cancer of prostate specimens were collected as observation group,30 cases of patients with benign prostate hyperplasia prostate tissue as control group,analyzed the expressions of XAGE-1 b and CD133 in the two groups by immunohistochemical,analyzing its different clinical and pathological features of expression differences.Results The observation group in XAGE-lb and CD133 expression positive rate were significantly higher than those in the control group,the difference was statistically significant (P ＜ 0.01),XAGE-1b and CD133 expression in prostate cancer and pathological clinical staging,metastasis and other indicators are closely related(P ＜0.05).Conclusions XAGE-1b and CD133 is highly expressed in cancer of prostate,and can be an ideal target for tumor immunotherapy.