CAJ | 학술논문

嵌合体是指同一个体中同时存在两个或多个不同细胞系的现象,在人类中比较罕见,一般是由于观察到血型或者性染色体异常才发现此种现象.目前,已陆续发现了多种类型的嵌合体,对其临床与实验室的研究取得了初步进展,但对于嵌合体的认识,特别是对其形成机制了解得尚不充分.该文中,回顾了以往文献对先天性嵌合体案例的报道及相关研究,并在其基础上总结了嵌合体的类型、形成机制、检测方法及诊断策略,以期进一步促进嵌合体的相关研究.
감합체시지동일개체중동시존재량개혹다개불동세포계적현상,재인류중비교한견,일반시유우관찰도혈형혹자성염색체이상재발현차충현상.목전,이륙속발현료다충류형적감합체,대기림상여실험실적연구취득료초보진전,단대우감합체적인식,특별시대기형성궤제료해득상불충분.해문중,회고료이왕문헌대선천성감합체안례적보도급상관연구,병재기기출상총결료감합체적류형、형성궤제、검측방법급진단책략,이기진일보촉진감합체적상관연구.
A chimera is produced by the fusion of two or more different zygotes in a single embryo.The chimerism has been rarely reported in humans.It is usually discovered because a discrepancy is observed in blood typing or sex chromosome complement.So far,several types of chimera have been discovered.However,the underlying mechanisms are poorly understood.In this article,the previous literatures which involved chimerism are reviewed,and the types of chimera,formation mechanisms,detected methods,and diagnostic strategies are summarized.We hope it is helpful to the research of chimera.