CAJ | 학술논문

目的观察细胞周期素G2 (CCNG2)和M2型丙酮酸激酶(PKM2)在胃癌组织中的表达,探讨两者与胃癌临床病理特征的关系及预后价值.方法应用免疫组织化学法检测51例胃癌患者手术切除的癌组织和癌旁组织中CCNG2和PKM2表达水平.结果 CCNG2在胃癌组织的表达率明显低于癌旁组织(62.75％比94.12％,P＜0.01),CCNG2表达水平与胃癌组织学分化程度、TNM分期、淋巴结转移明显相关(P＜0.05);PKM2在胃癌组织的表达率明显高于癌旁组织(72.55％比27.45％,P＜0.01),PKM2表达水平与胃癌TNM分期、淋巴结转移明显相关(P＜0.05).结论 CCNG2和PKM2在胃癌的发生、发展中发挥重要作用.
목적 관찰세포주기소G2 (CCNG2)화M2형병동산격매(PKM2)재위암조직중적표체,탐토량자여위암림상병리특정적관계급예후개치.방법 응용면역조직화학법검측51례위암환자수술절제적암조직화암방조직중CCNG2화PKM2표체수평.결과 CCNG2재위암조직적표체솔명현저우암방조직(62.75％비94.12％,P＜0.01),CCNG2표체수평여위암조직학분화정도、TNM분기、림파결전이명현상관(P＜0.05);PKM2재위암조직적표체솔명현고우암방조직(72.55％비27.45％,P＜0.01),PKM2표체수평여위암TNM분기、림파결전이명현상관(P＜0.05).결론 CCNG2화PKM2재위암적발생、발전중발휘중요작용.
Objective To study the expression of Cyclin G2 (CCNG2) and M2-pyruvate kinase (PKM2) in gastric carcinoma and their clinical significances.Methods The expression levels of CCNG2 and PKM2 in 51 cases of gastric carcinoma tissues and adjacent gastric tissues (5 cm distance away from the margin of gastric carcinoma) were detected by using immunohistochemical method.Results The expression rate of CCNG2 in gastric carcinoma tissues was lower than that of non-cancerous adjacent gastric tissues (62.75％ vs.94.12％,P ＜0.01).The expression of CCNG2 was related to histology grade,TNM stage and lymph node metastasis (P ＜ 0.05).The expression rate of PKM2 in gastric carcinoma tissues was higher than that of non-cancerous adjacent gastric tissues (72.55％ vs.27.45％,P ＜ 0.01),and the expression of PKM2 was related with TNM stage and lymph node metastasis (P ＜ 0.05).Conclusion CCNG2 and PKM2 are closely correlated to carcinogenesis,development and metastasis of gastric carcinoma,indicating they may be used as biological indicators to evaluate the degree of malignancy of gastric carcinoma.