中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2014年
2期
150-153
,共4页
颜利求%曹绪芬%郑晔%郭楠%熊立新%曹艳超%赵世龙%郭艳芬%韩立宪
顏利求%曹緒芬%鄭曄%郭楠%熊立新%曹豔超%趙世龍%郭豔芬%韓立憲
안리구%조서분%정엽%곽남%웅립신%조염초%조세룡%곽염분%한립헌
肾功能不全,慢性%冠状动脉疾病%体层摄影术,螺旋计算机
腎功能不全,慢性%冠狀動脈疾病%體層攝影術,螺鏇計算機
신공능불전,만성%관상동맥질병%체층섭영술,라선계산궤
Renal insufficiency,chronic%Coronary artery disease%Tomography,spiral computed
目的 分析老年患者慢性肾功能不全与冠状动脉(冠脉)钙化积分(CACS)的相关性.方法 前瞻性连续性入选2006年1月至2010年12月因疑诊冠心病于我院行64层螺旋CT的老年患者795例,应用Agatston方法计算CACS,应用简化MDRD公式计算估算肾小球滤过率(eGFR).根据CACS将患者分为4组:无冠脉钙化组(CACS=0)、低冠脉钙化组(CACS 1～100)、中冠脉钙化组(CACS 101～400)以及高冠脉钙化组(CACS＞400).通过有序Logistic回归分析慢性肾功能不全与冠状动脉钙化积分的相关性. 结果 高冠脉钙化组患者年龄大(F=4.99,P=0.002),eGFR低(F=10.16,P＜0.001),C反应蛋白水平高(F=39.36,P＜0.001),高血压(x2=18.59,P＜0.001)、糖尿病(x2=14.03,P=0.003)的患病率高.有序Logistic回归分析表明年龄、高血压、糖尿病、C反应蛋白及eGFR是冠状动脉钙化的独立危险因素. 结论 年龄、高血压、糖尿病、C反应蛋白及eGFR是老年患者冠状动脉钙化的独立危险因素.
目的 分析老年患者慢性腎功能不全與冠狀動脈(冠脈)鈣化積分(CACS)的相關性.方法 前瞻性連續性入選2006年1月至2010年12月因疑診冠心病于我院行64層螺鏇CT的老年患者795例,應用Agatston方法計算CACS,應用簡化MDRD公式計算估算腎小毬濾過率(eGFR).根據CACS將患者分為4組:無冠脈鈣化組(CACS=0)、低冠脈鈣化組(CACS 1～100)、中冠脈鈣化組(CACS 101～400)以及高冠脈鈣化組(CACS＞400).通過有序Logistic迴歸分析慢性腎功能不全與冠狀動脈鈣化積分的相關性. 結果 高冠脈鈣化組患者年齡大(F=4.99,P=0.002),eGFR低(F=10.16,P＜0.001),C反應蛋白水平高(F=39.36,P＜0.001),高血壓(x2=18.59,P＜0.001)、糖尿病(x2=14.03,P=0.003)的患病率高.有序Logistic迴歸分析錶明年齡、高血壓、糖尿病、C反應蛋白及eGFR是冠狀動脈鈣化的獨立危險因素. 結論 年齡、高血壓、糖尿病、C反應蛋白及eGFR是老年患者冠狀動脈鈣化的獨立危險因素.
목적 분석노년환자만성신공능불전여관상동맥(관맥)개화적분(CACS)적상관성.방법 전첨성련속성입선2006년1월지2010년12월인의진관심병우아원행64층라선CT적노년환자795례,응용Agatston방법계산CACS,응용간화MDRD공식계산고산신소구려과솔(eGFR).근거CACS장환자분위4조:무관맥개화조(CACS=0)、저관맥개화조(CACS 1～100)、중관맥개화조(CACS 101～400)이급고관맥개화조(CACS＞400).통과유서Logistic회귀분석만성신공능불전여관상동맥개화적분적상관성. 결과 고관맥개화조환자년령대(F=4.99,P=0.002),eGFR저(F=10.16,P＜0.001),C반응단백수평고(F=39.36,P＜0.001),고혈압(x2=18.59,P＜0.001)、당뇨병(x2=14.03,P=0.003)적환병솔고.유서Logistic회귀분석표명년령、고혈압、당뇨병、C반응단백급eGFR시관상동맥개화적독립위험인소. 결론 년령、고혈압、당뇨병、C반응단백급eGFR시노년환자관상동맥개화적독립위험인소.
Objective To investigate the association between chronic kidney dysfunction and coronary artery calcification score(CACS) in the elderly.Methods We prospectively studied 795 consecutive elderly patients with clinically suspected coronary artery disease who underwent 64-multidetector row computed tomography coronary angiography from January 2006 to December 2010.CACS was quantified using Agatston method.eGFR was calculated by the simplified modification of diet in renal disease(MDRD)equation.Patients were divided into four groups according to CACS as follows:No CACS(CACS =0),low CACS(0＜CACS≤100),medium CACS(100＜CACS≤400) and high CACS (CACS＞ 400).Ordinal logistic regression was used to analyze the association of chronic kidney dysfunction with CACS.Results Patients with higher CACS were older (F=4.99,P＜0.01),had lower eGFR(F=10.16,P＜0.001)and higher level of C-reactive protein(F=39.36,P ＜0.001),and were more likely to have a history of hypertension(x2 =18.59,P＜0.001) and diabetes (x2=14.03,P＜0.01)than patients without coronary artery calcification(CAC) or with lower CACS.Ordinal logistic regression showed that age,hypertension,diabetes,C-reactive protein and eGFR were independent risk factors for CAC.Conclusions Age,hypertension,diabetes mellitus,C-reactive protein and eGFR were independent risk factors for CAC in elderly patients.
