东南大学学报（医学版）
東南大學學報（醫學版）
동남대학학보（의학판）
JOURNAL OF SOUTHEAST UNIVERSITY(MEDICAL SCIENCE EDITION)
2014年
2期
159-161
,共3页
妊娠肝内胆汁淤积症%茵陈加味汤%熊去氧胆酸%中西医治疗
妊娠肝內膽汁淤積癥%茵陳加味湯%熊去氧膽痠%中西醫治療
임신간내담즙어적증%인진가미탕%웅거양담산%중서의치료
intrahepatic cholestasis of pregnancy%modified Artemisiae Scopariae decoction%ursodeoxycholic acid%treatment of traditional Chinese and Western Medicine
目的：观察茵陈加味汤联合熊去氧胆酸治疗妊娠肝内胆汁淤积症（ intrahepatic cholestasis of pregnancy，ICP）的疗效。方法：采用前瞻性研究方法，将2010年至2012年本院收治的妊娠肝内胆汁淤积症孕妇108例随机分为A、B两组，A组采用茵陈加味汤联合熊去氧胆酸治疗（62例），B组采用熊去氧胆酸治疗（46例）。比较两组治疗效果及妊娠结局。结果：治疗结束时，A组治疗后皮肤瘙痒评分及TBA、AST、ALT、CG值均降低，且较B组低。两组瘙痒评分和AST、ALT值比较差异有统计学意义（ P＜0．05），剖宫产率、产后出血率、羊水粪染率比较差异也有统计学意义（P＜0．05）。结论：茵陈加味汤联合熊去氧胆酸治疗ICP能够提高ICP的疗效，值得临床推广。
目的：觀察茵陳加味湯聯閤熊去氧膽痠治療妊娠肝內膽汁淤積癥（ intrahepatic cholestasis of pregnancy，ICP）的療效。方法：採用前瞻性研究方法，將2010年至2012年本院收治的妊娠肝內膽汁淤積癥孕婦108例隨機分為A、B兩組，A組採用茵陳加味湯聯閤熊去氧膽痠治療（62例），B組採用熊去氧膽痠治療（46例）。比較兩組治療效果及妊娠結跼。結果：治療結束時，A組治療後皮膚瘙癢評分及TBA、AST、ALT、CG值均降低，且較B組低。兩組瘙癢評分和AST、ALT值比較差異有統計學意義（ P＜0．05），剖宮產率、產後齣血率、羊水糞染率比較差異也有統計學意義（P＜0．05）。結論：茵陳加味湯聯閤熊去氧膽痠治療ICP能夠提高ICP的療效，值得臨床推廣。
목적：관찰인진가미탕연합웅거양담산치료임신간내담즙어적증（ intrahepatic cholestasis of pregnancy，ICP）적료효。방법：채용전첨성연구방법，장2010년지2012년본원수치적임신간내담즙어적증잉부108례수궤분위A、B량조，A조채용인진가미탕연합웅거양담산치료（62례），B조채용웅거양담산치료（46례）。비교량조치료효과급임신결국。결과：치료결속시，A조치료후피부소양평분급TBA、AST、ALT、CG치균강저，차교B조저。량조소양평분화AST、ALT치비교차이유통계학의의（ P＜0．05），부궁산솔、산후출혈솔、양수분염솔비교차이야유통계학의의（P＜0．05）。결론：인진가미탕연합웅거양담산치료ICP능구제고ICP적료효，치득림상추엄。
Objective: to observe the efficacy of ursodeoxycholic acid combined with modified Artemisiae Scopariae decoction in the treatment for intrahepatic cholestasis of pregnancy .Methods:108 cases with ICP had been chosen and randomly divided into two groups:the A group( the ursodeoxycholic acid combined with modified Artemisiae Scopariae decoction group ,62 case ) and the B group ( the ursodeoxycholic acid group ,46 case ) , the clinical effect were compared before and after traetment .Results:The reduction of itch score , AST,ALT of the A group were significantly decreased than that in the B group ( P <0.05 ) .The TBA, CG of the A group were decreased than in the B group .Comparing the two groups , the incident of Cesarean section , Postpartum hemorrhage and the incident of meconium-stained amniotic fluid were significant (P<0.05).Conclusion:It is effective to treat ICP with combination of ursodeoxycholic acid and modified Artemisiae Scopariae decoction injection .
