国际妇产科学杂志
國際婦產科學雜誌
국제부산과학잡지
JOURNAL OF INTERNATIONAL OBSTETRICS AND GYNECOLOGY
2014年
2期
184-185
,共2页
卵巢肿瘤%EphrinA3%免疫组织化学%基因%肿瘤抑制
卵巢腫瘤%EphrinA3%免疫組織化學%基因%腫瘤抑製
란소종류%EphrinA3%면역조직화학%기인%종류억제
Ovarian neoplasms%EphrinA3%Immunohistochemistry%Genes%Tumor suppressor
目的：检测上皮性卵巢癌组织中EphrinA3的表达水平，初步探讨EphrinA3在卵巢癌发病中的作用。方法：采用免疫组化方法检测上皮性卵巢癌组织中EphrinA3蛋白表达。结果：EphrinA3在卵巢癌组织中阳性表达率为73.3%，高于良性卵巢肿瘤组织（20%）及正常卵巢组织（16.7%）；Ⅲ~Ⅳ期卵巢癌组织中EphrinA3阳性表达率高于Ⅰ~Ⅱ期（83.3%vs.33.3%，P＜0.01）；在低分化卵巢癌组织中阳性表达率高于中高分化癌组织（80%vs.40%，P＜0.01）；在淋巴结转移组EphrinA3阳性表达率为88.9%，高于无转移组的50%（P＜0.05）。结论：EphrinA3在上皮性卵巢癌组织中高表达，在不同临床分期及组织学分级中，EphrinA3的表达水平不同。
目的：檢測上皮性卵巢癌組織中EphrinA3的錶達水平，初步探討EphrinA3在卵巢癌髮病中的作用。方法：採用免疫組化方法檢測上皮性卵巢癌組織中EphrinA3蛋白錶達。結果：EphrinA3在卵巢癌組織中暘性錶達率為73.3%，高于良性卵巢腫瘤組織（20%）及正常卵巢組織（16.7%）；Ⅲ~Ⅳ期卵巢癌組織中EphrinA3暘性錶達率高于Ⅰ~Ⅱ期（83.3%vs.33.3%，P＜0.01）；在低分化卵巢癌組織中暘性錶達率高于中高分化癌組織（80%vs.40%，P＜0.01）；在淋巴結轉移組EphrinA3暘性錶達率為88.9%，高于無轉移組的50%（P＜0.05）。結論：EphrinA3在上皮性卵巢癌組織中高錶達，在不同臨床分期及組織學分級中，EphrinA3的錶達水平不同。
목적：검측상피성란소암조직중EphrinA3적표체수평，초보탐토EphrinA3재란소암발병중적작용。방법：채용면역조화방법검측상피성란소암조직중EphrinA3단백표체。결과：EphrinA3재란소암조직중양성표체솔위73.3%，고우량성란소종류조직（20%）급정상란소조직（16.7%）；Ⅲ~Ⅳ기란소암조직중EphrinA3양성표체솔고우Ⅰ~Ⅱ기（83.3%vs.33.3%，P＜0.01）；재저분화란소암조직중양성표체솔고우중고분화암조직（80%vs.40%，P＜0.01）；재림파결전이조EphrinA3양성표체솔위88.9%，고우무전이조적50%（P＜0.05）。결론：EphrinA3재상피성란소암조직중고표체，재불동림상분기급조직학분급중，EphrinA3적표체수평불동。
Objective:Detection of EphrinA3 expression level in epithelial ovarian cancer tissue ,preliminary to explore EphrinA3 role in ovarian cancer. Methods:Immunohistochemistry was used to detect the expression of the EphrinA3 protein. Results:Positive expression rate of EphrinA3 in ovarian cancer was 73.3%,significantly higher than that in benign ovarian tumors (20%) and normal ovaries (16.7%); Ⅲ-Ⅳovarian cancer tissue EphrinA3 positive expression rate was significantly higher thanⅠ-Ⅱphase (83.3%vs. 33.3%,P<0.01);poorly differentiated ovarian carcinoma,the positive expression rate was significantly higher than in well-differentiated ovarian carcinoma (80%vs. 40%,P<0.01);EphrinA3 positive expression in lymph node metastasis group was significantly higher than no metastasis group (88.9%vs. 50%,P<0.05),and regardless of the histopathological type (P>0.05). Conclusions:High EphrinA3 expression was in epithelial ovarian cancer,and different expression levels of EphrinA3 were different in different clinical stage and histological grade.
