中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
18期
17-18,19
,共3页
抑郁症%阿立哌唑%汉密尔顿抑郁量表%副反应量表
抑鬱癥%阿立哌唑%漢密爾頓抑鬱量錶%副反應量錶
억욱증%아립고서%한밀이돈억욱량표%부반응량표
Depression%Aripiprazole%Hamilton Depression Scale%Treatment Emergent Symptom Scale
目的：探讨阿立哌唑合并抗抑郁药(三环类抗抑郁剂阿米替林)治疗抑郁症的临床疗效及安全性。方法选择120例抑郁症患者随机分为研究组和对照组。对照组给予常规抗抑郁药物治疗，研究组在常规抗抑郁治疗基础上给予阿立哌唑。采用汉密尔顿抑郁量表和副反应量表对两组患者治疗前和治疗后进行评定。结果研究组治疗后的第1、2、4、6周汉密尔顿抑郁量表评分分别与对照组同期比较，差异有统计学意义(P<0.05)。研究组治疗后的总有效率高于对照组，差异有统计学意义(P<0.05)。研究组副反应量表评分和对照组比较，差异无统计学意义(P>0.05)。结论阿立哌唑能够提高抗抑郁药(三环类抗抑郁剂阿米替林)治疗抑郁症的临床治疗效果，可作为临床抗抑郁治疗的一种增效手段。
目的：探討阿立哌唑閤併抗抑鬱藥(三環類抗抑鬱劑阿米替林)治療抑鬱癥的臨床療效及安全性。方法選擇120例抑鬱癥患者隨機分為研究組和對照組。對照組給予常規抗抑鬱藥物治療，研究組在常規抗抑鬱治療基礎上給予阿立哌唑。採用漢密爾頓抑鬱量錶和副反應量錶對兩組患者治療前和治療後進行評定。結果研究組治療後的第1、2、4、6週漢密爾頓抑鬱量錶評分分彆與對照組同期比較，差異有統計學意義(P<0.05)。研究組治療後的總有效率高于對照組，差異有統計學意義(P<0.05)。研究組副反應量錶評分和對照組比較，差異無統計學意義(P>0.05)。結論阿立哌唑能夠提高抗抑鬱藥(三環類抗抑鬱劑阿米替林)治療抑鬱癥的臨床治療效果，可作為臨床抗抑鬱治療的一種增效手段。
목적：탐토아립고서합병항억욱약(삼배류항억욱제아미체림)치료억욱증적림상료효급안전성。방법선택120례억욱증환자수궤분위연구조화대조조。대조조급여상규항억욱약물치료，연구조재상규항억욱치료기출상급여아립고서。채용한밀이돈억욱량표화부반응량표대량조환자치료전화치료후진행평정。결과연구조치료후적제1、2、4、6주한밀이돈억욱량표평분분별여대조조동기비교，차이유통계학의의(P<0.05)。연구조치료후적총유효솔고우대조조，차이유통계학의의(P<0.05)。연구조부반응량표평분화대조조비교，차이무통계학의의(P>0.05)。결론아립고서능구제고항억욱약(삼배류항억욱제아미체림)치료억욱증적림상치료효과，가작위림상항억욱치료적일충증효수단。
Objective To study clinical effect and safety of aripiprazole combined with antidepressants(tricyclic antidepressants amitriptyline) in the treatment of depression. Methods From January 2010 to December 2013, 120 patients with depression patients were selected and randomly divided into study group and control group , control group was given regular treatment of antidepressant drugs, study group was given aripiprazole combined with antidepressants(tricyclic antidepressants amitriptyline). The Hamilton Depression Scale (HAMD) and Treatment Emergent Symptom Scale (TESS) were used in the two group s of patients before and after treatment. Results Hamilton Depression Scale scores in the study group after treatment of the first week, second week, fourth week and sixth week of study group was compared with those in control group , the difference was statistically significant(P<0.05). The total efficacy rate in study group was higher than that in control group , the difference was statistically significant(P<0.05);there was no statistically significant of the side effects scale score in observation group compared with control group(P>0.05). Conclusion Aripiprazole can improve the clinical efficacy of antidepressants (tricyclic antidepressants amitriptyline) in the treatment of depression, which can be one of the augmentations in the treatment of depression.
