中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2013年
8期
533-536
,共4页
干燥综合征%免疫球蛋白G%IgG4相关性疾病
榦燥綜閤徵%免疫毬蛋白G%IgG4相關性疾病
간조종합정%면역구단백G%IgG4상관성질병
Sj(o)gren's syndrome%Immunoglobulin G%IgG4-related diseases
目的 探讨分析IgG亚类在原发性干燥综合征(pSS)患者中的临床意义.方法 pSS血清库中随机检测101例pSS患者、40名健康对照血清,应用免疫散射比浊法检测IgG亚类,分析比较pSS患者和健康对照者IgG亚类分布的差异,并结合临床资料,分析不同临床特征pSS患者与IgG亚类的相关性.计量资料正态分布者组间比较用t检验.结果 40名健康对照IgG 1～4平均值分别为(8085±1566)mg/L,(5406±2151) mg/L,(395±233) mg/L,(566±420) mg/L,所占IgG百分比为(56.8±8.2)％,(36.6±7.8)％,(2.7±1.5)％,(3.9±2.8)％；101例pSS患者IgG1～4均值分别为(14 094±5534) mg/L,(3915±1750)mg/L,(565±565) mg/L,(404±504) mg/L,所占IgG百分比为(73.0±10.9)％,(21.7±9.8)％,(3.1±2.0)％,(2.2±2.4)％.同健康对照者比较,pSS患者血清中IgG1、IgG3和IgG1/IgG增高,IgG2、IgG2/IgG和IgG4/IgG下降,差异均有统计学意义(P＜0.05); IgG4、IgG3/IgG下降,但差异无统计学意义(P＞0.05).pSS患者中系统受累组与非系统受累组比较,IgG亚类分布特征差异无计学意义(P＞0.05).IgG正常的pSS患者与健康对照相比,也存在IgG亚类分布异常.结论 pSS患者存在特征性IgG亚类分布异常,而抗SSA抗体产生主要与IgG1增高有关,未发现pSS系统受累与IgG亚类分布异常的相关性.
目的 探討分析IgG亞類在原髮性榦燥綜閤徵(pSS)患者中的臨床意義.方法 pSS血清庫中隨機檢測101例pSS患者、40名健康對照血清,應用免疫散射比濁法檢測IgG亞類,分析比較pSS患者和健康對照者IgG亞類分佈的差異,併結閤臨床資料,分析不同臨床特徵pSS患者與IgG亞類的相關性.計量資料正態分佈者組間比較用t檢驗.結果 40名健康對照IgG 1～4平均值分彆為(8085±1566)mg/L,(5406±2151) mg/L,(395±233) mg/L,(566±420) mg/L,所佔IgG百分比為(56.8±8.2)％,(36.6±7.8)％,(2.7±1.5)％,(3.9±2.8)％；101例pSS患者IgG1～4均值分彆為(14 094±5534) mg/L,(3915±1750)mg/L,(565±565) mg/L,(404±504) mg/L,所佔IgG百分比為(73.0±10.9)％,(21.7±9.8)％,(3.1±2.0)％,(2.2±2.4)％.同健康對照者比較,pSS患者血清中IgG1、IgG3和IgG1/IgG增高,IgG2、IgG2/IgG和IgG4/IgG下降,差異均有統計學意義(P＜0.05); IgG4、IgG3/IgG下降,但差異無統計學意義(P＞0.05).pSS患者中繫統受纍組與非繫統受纍組比較,IgG亞類分佈特徵差異無計學意義(P＞0.05).IgG正常的pSS患者與健康對照相比,也存在IgG亞類分佈異常.結論 pSS患者存在特徵性IgG亞類分佈異常,而抗SSA抗體產生主要與IgG1增高有關,未髮現pSS繫統受纍與IgG亞類分佈異常的相關性.
목적 탐토분석IgG아류재원발성간조종합정(pSS)환자중적림상의의.방법 pSS혈청고중수궤검측101례pSS환자、40명건강대조혈청,응용면역산사비탁법검측IgG아류,분석비교pSS환자화건강대조자IgG아류분포적차이,병결합림상자료,분석불동림상특정pSS환자여IgG아류적상관성.계량자료정태분포자조간비교용t검험.결과 40명건강대조IgG 1～4평균치분별위(8085±1566)mg/L,(5406±2151) mg/L,(395±233) mg/L,(566±420) mg/L,소점IgG백분비위(56.8±8.2)％,(36.6±7.8)％,(2.7±1.5)％,(3.9±2.8)％；101례pSS환자IgG1～4균치분별위(14 094±5534) mg/L,(3915±1750)mg/L,(565±565) mg/L,(404±504) mg/L,소점IgG백분비위(73.0±10.9)％,(21.7±9.8)％,(3.1±2.0)％,(2.2±2.4)％.동건강대조자비교,pSS환자혈청중IgG1、IgG3화IgG1/IgG증고,IgG2、IgG2/IgG화IgG4/IgG하강,차이균유통계학의의(P＜0.05); IgG4、IgG3/IgG하강,단차이무통계학의의(P＞0.05).pSS환자중계통수루조여비계통수루조비교,IgG아류분포특정차이무계학의의(P＞0.05).IgG정상적pSS환자여건강대조상비,야존재IgG아류분포이상.결론 pSS환자존재특정성IgG아류분포이상,이항SSA항체산생주요여IgG1증고유관,미발현pSS계통수루여IgG아류분포이상적상관성.
Objective To investigate the clinical significance of IgG subclasses in patients with primary Sj(o)gren's syndrome (pSS) patients.Methods The serum was collected from 101 pSS patients and 40 healthy subjects.The content of IgG subclasses was determined by immuno-scatter turbidmetry.The difference of IgG subclasses distribution between pSS patients and healthy subjects was analyzed.Com-bined with the clinical information of the SS patients,the difference of IgG subclasses distribution in SS patients with different characteristics was analyzed.For group comparisons,measurement data were compared using unpaired Student's t test.Results The average levels of serum IgG1-4 in 40 healthy controls were (8085±1566) mg/L,(5406±2151) mg/L,(395±233) mg/L and (566±420) mg/L.The percentage of IgG1-4 were (56.8±8.2)％,(36.6±7.8)％,(2.7±1.5)％ and (3.9±2.8)％.The average levels of serum IgG1-4 in 101 pSS patients were (14 094±5534) mg/L,(3912±1750) mg/L,(565±565) mg/L and (404±504) mg/L,The percentage of IgG1-4 were(73.0±10.9)％,(21.7±9.8)％,(3.1±2.0)％ and (2.2±2.4)％.In pSS patients,the levels of IgG1,IgG3 and IgG1/IgG were significantly higher,while the IgG2,IgG2/IgG and IgG4/IgG levels were significantly lower,compared with those of the healthy subjects (P＜0.05).There was no significant difference in the IgG subclasses distribution between the pSS patients whose had systemic involvement and the pSS patients who did not have systemic involvement(P＞0.05).The IgG subclasses distribution was abnormal in SS patients who IgG was normal,compared with the healthy subjects.Conclusion A characteristic IgG subclasses distribution abnormality exists in pSS patients,and the production of anti-SSA (Sj(o)gren's syndrome A) antibody is associated with the increase of IgG1.However,no relationship has been found between the systemic involvement of pSS patients and the abnormal distribution of IgG subclasses.
